Liu Peng Cheng, Yan Yu Ke, Ma Yu Jing, Wang Xiang Wen, Geng Jie, Wang Man Cai, Wei Feng Xian, Zhang Ya Wu, Xu Xiao Dong, Zhang You Cheng
Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China.
Hepato-Biliary-Pancreatic Institute, Lanzhou University Second Hospital, Lanzhou 730030, China.
Gastroenterol Res Pract. 2017;2017:6029075. doi: 10.1155/2017/6029075. Epub 2017 Apr 6.
We performed this meta-analysis to investigate the efficacy of probiotics on prevention of infection-related complications following colorectal resection. PubMed, EMBASE, Cochrane Library, and the Web of Science were searched up to January 2016. According to the results, only randomized controlled trials that compared the efficacy of probiotics on patients with colorectal resection were included for meta-analysis. Nine studies including a total of 1146 patients met the criteria (556 received multistrain probiotic bacteria, 590 with non-multistrain probiotic bacteria). The combination of multistrain probiotics was beneficial in the reduction of total infections (OR = 0.30, 95%CI: 0.15-0.61, = 0.0009), including surgical site infections (SSI) (OR = 0.48, 95%CI: 0.25-0.89, = 0.02) and nonsurgical site infections (NSSI) (OR = 0.36, 95%CI: 0.23-0.56, < 0.00001). However, there was no significant reduction in total infections (OR = 0.74, 95%CI: 0.50-1.09, = 0.13) or SSI (OR = 0.77, 95%CI: 0.52-1.12, = 0.17) with the application of non-multistrains of probiotics. Combinations of multistrain probiotic bacteria showed promise in preventing the incidence of infections following colorectal surgery. However, the efficacy of one or two strains of probiotics remains undetermined.
我们进行了这项荟萃分析，以研究益生菌对预防结直肠切除术后感染相关并发症的疗效。检索了截至2016年1月的PubMed、EMBASE、Cochrane图书馆和科学网。根据结果，仅纳入比较益生菌对结直肠切除患者疗效的随机对照试验进行荟萃分析。9项研究共1146例患者符合标准（556例接受多菌株益生菌，590例接受非多菌株益生菌）。多菌株益生菌组合有助于减少总感染（OR = 0.30，95%CI：0.15 - 0.61，P = 0.0009），包括手术部位感染（SSI）（OR = 0.48，95%CI：0.25 - 0.89，P = 0.02）和非手术部位感染（NSSI）（OR = 0.36, 95%CI: 0.23 - 0.56, P < 0.00001）。然而，应用非多菌株益生菌时，总感染（OR = 0.74，95%CI：0.50 - 1.09，P = 0.13）或SSI（OR = 0.77，95%CI：0.52 - 1.12，P = 0.17）没有显著降低。多菌株益生菌组合在预防结直肠手术后感染发生率方面显示出前景。然而，一两种菌株益生菌的疗效仍未确定。
