用于结直肠癌手术患者术后感染的益生菌。

Probiotics Used for Postoperative Infections in Patients Undergoing Colorectal Cancer Surgery.

机构信息

Department of Intensive Care Unit, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.

Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

出版信息

Biomed Res Int. 2020 Jan 31;2020:5734718. doi: 10.1155/2020/5734718. eCollection 2020.

OBJECTIVE

The objective of this study was to conduct a systematic review and meta-analysis about probiotics to improve postoperative infections in patients undergoing colorectal cancer surgery.

METHODS

The PubMed and the Web of Science were used to search for appropriate randomized clinical trials (RCTs) comparing probiotics with placebo for the patients undergoing colorectal cancer surgery. The RevMan 5.3 was performed for meta-analysis to evaluate the postoperative infection, including the total infection, surgical site infection, central line infection, pneumonia, urinary tract infection, septicemia, and postoperative leakage.

RESULTS

Our meta-analysis included 6 studies involving a total of 803 patients. For the incidence of total postoperative infection (odd ratios (OR) 0.31, 95% confidence interval (CI) 0.15-0.64, = 0%), surgical site infection (OR 0.62, 95% CI 0.39-0.99, = 0%), surgical site infection (OR 0.62, 95% CI 0.39-0.99, = 0%), surgical site infection (OR 0.62, 95% CI 0.39-0.99, = 0%), surgical site infection (OR 0.62, 95% CI 0.39-0.99, = 0%), surgical site infection (OR 0.62, 95% CI 0.39-0.99, = 0%), surgical site infection (OR 0.62, 95% CI 0.39-0.99, = 0%), surgical site infection (OR 0.62, 95% CI 0.39-0.99.

CONCLUSIONS

Probiotics is beneficial to prevent postoperative infections (including total postoperative infection, surgical site infection, pneumonia, urinary tract infection, and septicemia) in patients with colorectal cancer.

目的

本研究旨在进行系统评价和荟萃分析，探讨益生菌对结直肠癌手术患者术后感染的改善作用。

方法

检索 PubMed 和 Web of Science 数据库，纳入比较益生菌与安慰剂用于结直肠癌手术患者的随机对照临床试验（RCT）。采用 RevMan 5.3 进行荟萃分析，评估术后感染（包括总感染、手术部位感染、中心静脉导管感染、肺炎、尿路感染、败血症和术后漏）的发生情况。

结果

本荟萃分析纳入 6 项研究，共 803 例患者。总术后感染发生率的荟萃分析结果显示（比值比（OR）0.31，95%置信区间（CI）0.15-0.64， = 0%）、手术部位感染（OR 0.62，95% CI 0.39-0.99， = 0%）、中心静脉导管感染（OR 0.62，95% CI 0.39-0.99， = 0%）、肺炎（OR 0.62，95% CI 0.39-0.99， = 0%）、尿路感染（OR 0.62，95% CI 0.39-0.99， = 0%）和败血症（OR 0.62，95% CI 0.39-0.99， = 0%）。