Geidenstam Nina, Magnusson Martin, Danielsson Anders P H, Gerszten Robert E, Wang Thomas J, Reinius Lovisa E, Mulder Hindrik, Melander Olle, Ridderstråle Martin
Department of Clinical Sciences Malmö, Clinical Obesity, Lund University Diabetes Center, Lund University, Malmö, Sweden.
Department of Cardiology, Skåne University Hospital, Malmö, Sweden.
Int J Endocrinol. 2017;2017:6490473. doi: 10.1155/2017/6490473. Epub 2017 Apr 16.
. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. . Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort ( = 83). . Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the ≥10% weight loss group with an associated change in BMI ( = 0.16-0.22, < 0.002), whereas the scores increased in the <10% weight loss group ( < 0.0004). . Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss.
我们研究了循环氨基酸水平与肥胖之间的关系；体重减轻后再维持体重能在多大程度上纠正氨基酸异常；以及氨基酸是否与体重减轻有关。在来自马尔默饮食与癌症心血管队列（MDC - CC）的804名参与者中研究了与腰围（WC）和体重指数（BMI）相关的氨基酸。对12名肥胖受试者体重减轻和体重维持后的氨基酸水平变化进行了分析，并在一个复制队列（n = 83）中进行了评估。在MDC - CC中确定的8种与BMI相关的氨基酸中，丙氨酸、异亮氨酸、酪氨酸、苯丙氨酸和谷氨酸在体重减轻后下降，而天冬酰胺在体重维持后增加。这些变化在复制队列中得到了验证。基于肥胖相关氨基酸和已知风险因素构建的评分在体重减轻≥10%的组中下降，同时BMI也有相关变化（r = 0.16 - 0.22，P < 0.002），而在体重减轻<10%的组中评分增加（P < 0.0004）。体重减轻后再维持体重会导致与肥胖相关的氨基酸水平发生不同变化。基于流行病学和干预数据的可治疗性评分可用于评估体重减轻的潜在代谢益处。
