Department of Clinical Sciences Malmö, Clinical Obesity, Lund University Diabetes Center, Lund University, Malmö, Sweden.
Department of Clinical Sciences Malmö, Unit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö, Sweden.
Int J Obes (Lond). 2017 Sep;41(9):1369-1378. doi: 10.1038/ijo.2017.124. Epub 2017 May 22.
We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.
Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a 1 year non-surgical weight loss program.ResultsA total of 137 metabolites were identified and semi-quantified at baseline (BMI 42.7±5.8, mean±s.d.) and at follow-up (BMI 36.3±6.6). Weight-loss-induced modification was observed for levels of 57 metabolites in individuals with ⩾10% weight loss. Lower baseline levels of xylitol was predictive of a greater decrease in BMI (β=0.06, P<0.01) and ⩾10% weight loss (odds ratio (OR)=0.2, confidence interval (CI)=0.07-0.7, P=0.01). Decreases in levels of isoleucine, leucine, valine and tyrosine were associated with decrease in BMI (β>0.1, P<0.05) and ⩾10% weight loss (isoleucine: OR=0.08, CI=0.01-0.3, leucine: OR=0.1, CI=0.01-0.6, valine: OR=0.1, CI=0.02-0.5, tyrosine: OR=0.1, CI=0.03-0.6, P<0.02).
Diet-induced weight loss leads to mainly reduced levels of metabolites that are elevated in obese insulin resistant individuals. We identified multiple new associations with metabolic risk factors and validated several previous findings related to weight loss-mediated metabolite changes. Levels of specific metabolites, such as xylitol, may be predictive of the response to non-surgical weight loss already at baseline.
我们和其他人之前已经描述了饮食诱导的体重减轻后循环代谢物水平的变化。我们的目的是研究基线代谢物水平以及这些水平的体重减轻诱导变化是否可预测或与体重指数（BMI）和代谢风险特征的变化相关。
在 91 名肥胖个体中，在基线时和参加非手术减肥计划 1 年后，使用气相和液相色谱/质谱法分析血清代谢物。
在基线（BMI 42.7±5.8，平均值±标准差）和随访（BMI 36.3±6.6）时鉴定并半定量了总共 137 种代谢物。在体重减轻≥10%的个体中，观察到 57 种代谢物水平的改变。基线时木糖水平较低与 BMI 下降更大（β=0.06，P<0.01）和体重减轻≥10%相关（优势比（OR）=0.2，置信区间（CI）=0.07-0.7，P=0.01）。异亮氨酸、亮氨酸、缬氨酸和酪氨酸水平的降低与 BMI 下降（β>0.1，P<0.05）和体重减轻≥10%相关（异亮氨酸：OR=0.08，CI=0.01-0.3；亮氨酸：OR=0.1，CI=0.01-0.6；缬氨酸：OR=0.1，CI=0.02-0.5；酪氨酸：OR=0.1，CI=0.03-0.6，P<0.02）。
饮食诱导的体重减轻主要导致代谢物水平降低，而肥胖胰岛素抵抗个体的代谢物水平升高。我们发现了与代谢风险因素的多个新关联，并验证了与体重减轻介导的代谢物变化相关的几个先前发现。在基线时，特定代谢物（如木糖）的水平可能可预测对非手术减肥的反应。
