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动脉调转术导致的胸主动脉几何形态变化对壁面剪应力分布的影响。

Influence of Geometric Changes in the Thoracic Aorta due to Arterial Switch Operations on the Wall Shear Stress Distribution.

作者信息

Fukui Tomohiro, Asama Hiroaki, Kimura Manabu, Itoi Toshiyuki, Morinishi Koji

机构信息

Department of Mechanical Engineering, Kyoto Institute of Technology, Matsugasaki Goshokaido-cho, Sakyo-ku, Kyoto 606-8585, Japan.

Kyoto Second Red Cross Hospital, Haruobi-cho 355-5, Kamigyo-ku, Kyoto 602-8026, Japan.

出版信息

Open Biomed Eng J. 2017 Feb 16;11:9-16. doi: 10.2174/1874120701711010009. eCollection 2017.

Abstract

BACKGROUND

The transposition of the great arteries (TGA) is one of the most severe congenital heart diseases. The arterial switch operation (ASO) is the preferred procedure to treat TGA. Although numerous reports have shown good results after ASOs, some patients suffer from circulatory system problems following the procedure. One reason for problems post-ASO is the local changes in the curvature and torsion of the thoracic aorta.

OBJECTIVE

The influence of these geometric changes on the blood flow field needs to be investigated in detail to consider possible cardiovascular problems after an ASO.

METHOD

In this study, we conduct blood flow simulations in the thoracic aorta post-ASO, evaluate geometric changes in the aorta due to the ASO in terms of curvature and torsion, and consider the effect of geometric changes on blood flow in the aorta.

RESULTS

It was found that a large curvature near the aortic root causes an increase in the maximal wall shear stress value in the middle systole. Moreover, a large torsion results in a circumferential change in the maximal wall shear stress region. It was also found that the maximal wall shear stress in the post-ASO models is significantly higher than that in the normal models. This indicates that the aortic aneurysm initiation risk for a post-ASO artery may be higher than that of a normal artery.

CONCLUSION

To reduce the risk of initiating an aneurism, it is suggested that the curvature near the aortic root should be decreased during the ASO.

摘要

背景

大动脉转位(TGA)是最严重的先天性心脏病之一。动脉调转手术(ASO)是治疗TGA的首选术式。尽管大量报告显示ASO术后效果良好,但部分患者术后存在循环系统问题。ASO术后出现问题的一个原因是胸主动脉曲率和扭转的局部改变。

目的

为了考虑ASO术后可能出现的心血管问题,需要详细研究这些几何变化对血流场的影响。

方法

在本研究中,我们对ASO术后的胸主动脉进行血流模拟,从曲率和扭转方面评估ASO导致的主动脉几何变化,并考虑几何变化对主动脉血流的影响。

结果

发现主动脉根部附近的大曲率会导致收缩中期最大壁面切应力值增加。此外,大扭转会导致最大壁面切应力区域的周向变化。还发现ASO术后模型中的最大壁面切应力明显高于正常模型。这表明ASO术后动脉发生主动脉瘤的风险可能高于正常动脉。

结论

为降低动脉瘤发生风险,建议在ASO过程中降低主动脉根部附近的曲率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ec/5395927/a3175b606dcb/TOBEJ-11-9_F1.jpg

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