Nagamine Hiroshi, Kishita Kenji, Tsukada Yuta, Nagano Hiroshi, Asano Mitsuru
Department of Cardiovascular Surgery, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
JTCVS Open. 2024 Sep 24;22:144-155. doi: 10.1016/j.xjon.2024.09.016. eCollection 2024 Dec.
A novel approach to 3-dimensional morphometry of the thoracic aorta was developed by applying centerline analysis based on least-squares plane fitting, and a preliminary study was conducted using computed tomography imaging data.
We retrospectively compared 3 groups of patients (16 controls without aortic disease, and 16 cases each with acute type B aortic dissection and congenital bicuspid aortic valve). In addition to the standard assessment indices for curvature κ and torsion τ, we conducted coordinate transformation based on the least-squares plane, divided the centerline into 3 representative features (transverse, anterior-posterior, and longitudinal displacements), and analyzed the overall and local displacement in each direction. The transverse displacement, represented by the distance of the centerline from the least-squares plane, was curve-fitted to the damped oscillation waveform. Thereafter, damped oscillation parameters were compared for each group.
Curvature κ exhibited a bimodal distribution, with peaks observed in the ascending aorta and aortic arch, and torsion τ exhibited a transition from positive to negative values in the arch. There were significant differences in the mean displacement between the groups for each direction (transverse = .0083, anteroposterior = .010, longitudinal = 1.32 × 10). Furthermore, interval integral analysis revealed that several intervals exhibited significant differences between groups in each direction. The amplitude of damped oscillation parameters was significantly larger in the bicuspid aortic valve group than in the control and type B aortic dissection groups.
The novel analytical approach permitted a quantitative assessment of the 3-dimensional morphological differences between the control, type B aortic dissection, and bicuspid aortic valve groups.
通过应用基于最小二乘平面拟合的中心线分析方法，开发一种用于胸主动脉三维形态测量的新方法，并使用计算机断层扫描成像数据进行初步研究。
我们回顾性比较了3组患者（16名无主动脉疾病的对照组，以及各16例急性B型主动脉夹层和先天性二叶式主动脉瓣患者）。除了曲率κ和扭转τ的标准评估指标外，我们基于最小二乘平面进行坐标变换，将中心线分为3个代表性特征（横向、前后向和纵向位移），并分析每个方向上的整体和局部位移。以中心线到最小二乘平面的距离表示的横向位移，被拟合成阻尼振荡波形。此后，比较了每组的阻尼振荡参数。
曲率κ呈现双峰分布，在升主动脉和主动脉弓处观察到峰值，扭转τ在主动脉弓处呈现从正值到负值的转变。每组在每个方向上的平均位移存在显著差异（横向 = 0.0083，前后向 = 0.010，纵向 = 1.32×10）。此外，区间积分分析显示，每组在每个方向上的几个区间存在显著差异。二叶式主动脉瓣组的阻尼振荡参数幅度明显大于对照组和B型主动脉夹层组。
这种新的分析方法允许对对照组、B型主动脉夹层组和二叶式主动脉瓣组之间的三维形态差异进行定量评估。
