生物膜以及抗生素在人工髋关节和膝关节周围感染治疗中的作用
Biofilm and the Role of Antibiotics in the Treatment of Periprosthetic Hip and Knee Joint Infections.
作者信息
Mirza Yusuf H, Tansey Rosamond, Sukeik Mohamed, Shaath Mohammed, Haddad Fares Sami
机构信息
Department of Trauma and Orthopaedics, University College London Hospital, 235 Euston Road, NW1 2BU, London, United Kingdom.
Department of Trauma and Orthopaedics, Royal London Hospital, Whitechapel, London, E1 1BB, United Kingdom.
出版信息
Open Orthop J. 2016 Nov 30;10:636-645. doi: 10.2174/1874325001610010636. eCollection 2016.
Abstract
An increasing demand for lower limb arthroplasty will lead to a proportionate increase in the need for revision surgery. A notable proportion of revision surgery is secondary to periprosthetic joint infections (PJI). Diagnosing and eradicating PJI can form a very difficult challenge. An important cause of PJI is the formation of a bacterial biofilm on the implant surface. Our review article seeks to describe biofilms; their definitions and formation, common causative bacteria, prophylactic and therapeutic antibiotic therapy.
摘要
对下肢关节置换术需求的不断增加将导致翻修手术需求相应增加。相当一部分翻修手术继发于假体周围关节感染（PJI）。诊断和根除PJI可能是一项极具挑战性的任务。PJI的一个重要原因是在植入物表面形成细菌生物膜。我们的综述文章旨在描述生物膜；它们的定义、形成、常见致病菌、预防性和治疗性抗生素治疗。
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