Akil Handan, Chopra Vikas, Huang Alex S, Swamy Ramya, Francis Brian A
Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.
Department of Ophthalmology, David Geffen School of Medicine, Los Angeles, CA, USA.
J Ophthalmol. 2017;2017:8248710. doi: 10.1155/2017/8248710. Epub 2017 Apr 17.
. To assess the safety and efficacy of Trabectome procedure in patients with preoperative intraocular pressure (IOP) of 30 mmHg or higher. . All patients who had underwent Trabectome stand-alone or Trabectome combined with phacoemulsification were included. Survival analysis was performed by using Kaplan-Meier, and success was defined as IOP ≤ 21 mmHg, 20% or more IOP reduction from baseline for any two consecutive visits after 3 months, and no secondary glaucoma surgery. . A total of 49 cases were included with an average age of 66 (range: 13-91). 28 cases had Trabectome stand-alone and 21 cases had Trabectome combined with phacoemulsification. Mean IOP was reduced from a baseline of 35.6 ± 6.3 mmHg to 16.8 ± 3.8 mmHg at 12 months ( < 0.01), while the number of medications was reduced from 3.1 ± 1.3 to 1.8 ± 1.4 ( < 0.01). Survival rate at 12 months was 80%. 9 cases required secondary glaucoma surgery, and 1 case was reported with hypotony at day one, but resolved within one week. . Trabectome seems to be safe and effective in patients with preoperative IOP of 30 mmHg or greater. Even in this cohort with high preoperative IOP, the end result is a mean IOP in the physiologic range.
评估Trabectome手术在术前眼压（IOP）为30 mmHg或更高的患者中的安全性和有效性。纳入所有接受单独Trabectome手术或Trabectome联合超声乳化手术的患者。采用Kaplan-Meier法进行生存分析，成功定义为眼压≤21 mmHg、术后3个月任何连续两次随访时眼压较基线降低20%或更多，且未进行二次青光眼手术。共纳入49例患者，平均年龄66岁（范围：13 - 91岁）。28例接受单独Trabectome手术，21例接受Trabectome联合超声乳化手术。12个月时平均眼压从基线的35.6±6.3 mmHg降至16.8±3.8 mmHg（P<0.01），而药物数量从3.1±1.3降至1.8±1.4（P<0.01）。12个月时生存率为80%。9例需要二次青光眼手术，1例在术后第1天出现低眼压，但在1周内缓解。Trabectome手术在术前眼压为30 mmHg或更高的患者中似乎是安全有效的。即使在这个术前眼压较高的队列中，最终结果是平均眼压处于生理范围内。
