Kwantwi Louis Boafo, Tunu Bismark Kwame, Boateng Daniel, Quansah Dan Yedu
Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
J Biomark. 2017;2017:7907352. doi: 10.1155/2017/7907352. Epub 2017 Apr 18.
. In view of the lack of evidence on the possibility of an economically viable, easy, and readily available biomarker to substitute the traditional role of CD4 counts in HIV disease progression, this study seeks to investigate the potential use of body mass index (BMI), haemoglobin (Hb), and total lymphocyte count (TLC) as surrogate biomarkers for monitoring the disease. . This cross-sectional study was undertaken at the antiretroviral clinic (ART) of the Bomso Hospital, Kumasi, Ghana. We recruited 384 individuals who were 18 years or older and confirmed HIV seropositive patients. Blood samples were assayed for TLC and Hb. Weight and height were determined and BMI was calculated. . At a cut-off point of 12.15 g/dL, Hb had sensitivity and specificity of 73.9% and 56.8%, respectively, whereas BMI had 69.6% and 80.1% sensitivity and specificity, respectively. The sensitivity and specificity were also 100% among the studied participants at a cut-off point of 1200 mm for TLC. There was a significant positive correlation between CD4 count and Hb (rho 0.262, = 0.0001), BMI (rho 0.301, = 0.0001), and TLC (rho 0.834, = 0.0001). . The study demonstrates that TLC, Hb, and BMI may provide some useful prognostic information independent of that provided by CD4 count.
鉴于缺乏证据表明存在一种经济上可行、简便且易于获得的生物标志物来替代CD4细胞计数在HIV疾病进展中的传统作用，本研究旨在调查体重指数（BMI）、血红蛋白（Hb）和总淋巴细胞计数（TLC）作为监测该疾病替代生物标志物的潜在用途。
这项横断面研究在加纳库马西邦索医院的抗逆转录病毒诊所（ART）进行。我们招募了384名18岁及以上且确诊为HIV血清阳性的患者。对血样进行TLC和Hb检测。测量体重和身高并计算BMI。
在截断点为12.15 g/dL时，Hb的敏感性和特异性分别为73.9%和56.8%，而BMI的敏感性和特异性分别为69.6%和80.1%。在截断点为1200/mm时，TLC在研究参与者中的敏感性和特异性也均为100%。CD4细胞计数与Hb（rho 0.262，p = 0.0001）、BMI（rho 0.301，p = 0.0001）和TLC（rho 0.834，p = 0.0001）之间存在显著正相关。
该研究表明，TLC、Hb和BMI可能提供一些独立于CD4细胞计数的有用预后信息。
