Kim Hee Jung, Park Jeong-Soo
Department of Physiology, Dankook University College of Medicine, Cheonan, Korea.
Department of Biochemistry, Dankook University College of Medicine, Cheonan, Korea.
Dev Reprod. 2017 Mar;21(1):1-10. doi: 10.12717/DR.2017.21.1.001. Epub 2017 Mar 31.
The use of human mesenchymal stem cells (hMSCs) in cell-based therapy has attracted extensive interest in the field of regenerative medicine, and it shows applications to numerous incurable diseases. hMSCs show several superior properties for therapeutic use compared to other types of stem cells. Different cell types are discussed in terms of their advantages and disadvantages, with focus on the characteristics of hMSCs. hMSCs can proliferate readily and produce differentiated cells that can substitute for the targeted affected tissue. To maximize the therapeutic effects of hMSCs, a substantial number of these cells are essential, requiring extensive cell expansion. However, hMSCs have a limited lifespan in an culture condition. The senescence of hMSCs is a double-edged sword from the viewpoint of clinical applications. Although their limited cell proliferation potency protects them from malignant transformation after transplantation, senescence can alter various cell functions including proliferation, differentiation, and migration, that are essential for their therapeutic efficacy. Numerous trials to overcome the limited lifespan of mesenchymal stem cells are discussed.
人间充质干细胞（hMSCs）在基于细胞的治疗中的应用在再生医学领域引起了广泛关注，并且显示出对多种不治之症的应用前景。与其他类型的干细胞相比，hMSCs在治疗用途上表现出若干优越特性。本文讨论了不同细胞类型的优缺点，重点是hMSCs的特性。hMSCs能够轻易增殖并产生可替代靶向受影响组织的分化细胞。为了使hMSCs的治疗效果最大化，大量此类细胞必不可少，这需要广泛的细胞扩增。然而，hMSCs在培养条件下的寿命有限。从临床应用的角度来看，hMSCs的衰老犹如一把双刃剑。尽管它们有限的细胞增殖能力可保护它们在移植后免于恶性转化，但衰老会改变包括增殖、分化和迁移在内的各种细胞功能，而这些功能对其治疗效果至关重要。本文还讨论了众多克服间充质干细胞有限寿命的试验。
