口蹄疫病毒（FMDV）重组体中的交叉区域对应于局部二级结构较高的区域。
Crossover regions in foot-and-mouth disease virus (FMDV) recombinants correspond to regions of high local secondary structure.
作者信息
Wilson V, Taylor P, Desselberger U
机构信息
Institute of Virology, University of Glasgow, Scotland.
出版信息
Arch Virol. 1988;102(1-2):131-9. doi: 10.1007/BF01315570.
Abstract
The RNA genome of foot-and-mouth disease virus (FMDV) was analysed for the degree of inverted complementarity and thus potential secondary structure using the procedure of Pustell and Kafatos [Nucleic Acids Res (1982) 10: 4765-4782]. Regions of crossover in 42 FMDV recombinants [King et al. (1985) Virus Res 3: 373-384; Saunders et al. (1985) J Virol 56: 921-929] and regions lacking crossovers were assigned an average secondary structure score against which the number of observed recombinants was plotted. In general it was found that the mean value of potential secondary structure is significantly higher in crossover zones than in recombination-free zones. Recombination increased much more steeply with increasing secondary structure in the part of the genome coding for non-structural proteins than in the 5' third of the genome coding for structural proteins.
摘要
采用普斯泰尔和卡法托斯的方法[《核酸研究》（1982年）10: 4765 - 4782]，分析口蹄疫病毒（FMDV）的RNA基因组的反向互补程度以及潜在的二级结构。对42个FMDV重组体中的交叉区域[金等人（1985年）《病毒研究》3: 373 - 384；桑德斯等人（1985年）《病毒学杂志》56: 921 - 929]和无交叉区域赋予平均二级结构得分，并据此绘制观察到的重组体数量。总体而言，发现交叉区域潜在二级结构的平均值显著高于无重组区域。与编码结构蛋白的基因组5'端三分之一区域相比，在编码非结构蛋白的基因组部分，随着二级结构增加，重组增加得更为陡峭。
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