Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Department of Health Care Science College of Health Sciences, Dong-A University, Busan, Korea.
Geriatr Gerontol Int. 2017 Nov;17(11):2053-2059. doi: 10.1111/ggi.13018. Epub 2017 May 9.
The aim of the present study was to investigate the association between various body composition parameters and the risk of mild cognitive impairment (MCI) in older Japanese adults, as well as potential sex-related differences in the risk of MCI.
Participants underwent cognitive tests, and were divided into 840 participants with MCI (mean age 71.9 ± 5.5 years) and 1740 without MCI (mean age 71.3 ± 5.2 years). Body composition parameters were measured using a bioelectrical impedance analyzer. Multiple logistic regression analysis was then carried out to examine the associations between body composition parameters and risk of MCI.
After adjusting for confounding factors, those in the lowest quartile for fat-free mass had a higher risk of MCI than those in the highest quartile (men: odds ratio [OR] 1.96, 95% confidence interval CI 1.24-3.10; women: OR 1.49, 95% CI 1.01-2.19). Loss of muscle mass in the upper (OR 2.17, 95% CI 1.40-3.37) and lower (OR 1.99, 95% CI 1.25-3.15) limbs was associated with a higher MCI risk in men. However, only loss of muscle mass in the lower limbs was associated with a higher MCI risk (OR 1.61, 95% CI 1.06-2.44) in women. No associations were found between obesity measures and MCI.
We found that loss of fat-free mass was associated with MCI in older adults, regardless of sex. We also found that appendicular muscle mass was more closely associated with MCI in men than in women. These results suggest that the association between appendicular muscle mass and MCI might have different underlying mechanisms based on sex. Geriatr Gerontol Int 2017; 17: 2053-2059.
本研究旨在探讨老年日本成年人各种身体成分参数与轻度认知障碍（MCI）风险之间的关系，以及 MCI 风险的潜在性别差异。
参与者接受认知测试，并分为 840 名 MCI 患者（平均年龄 71.9±5.5 岁）和 1740 名非 MCI 患者（平均年龄 71.3±5.2 岁）。使用生物电阻抗分析仪测量身体成分参数。然后进行多因素逻辑回归分析，以检查身体成分参数与 MCI 风险之间的关联。
在校正混杂因素后，脂肪量最低四分位的人患 MCI 的风险高于最高四分位的人（男性：比值比[OR]1.96，95%置信区间[CI]1.24-3.10；女性：OR1.49，95%CI1.01-2.19）。上肢（OR2.17，95%CI1.40-3.37）和下肢（OR1.99，95%CI1.25-3.15）肌肉质量的损失与男性 MCI 风险升高相关。然而，仅下肢肌肉质量的损失与女性 MCI 风险升高相关（OR1.61，95%CI1.06-2.44）。肥胖测量与 MCI 之间没有关联。
我们发现无论性别如何，非脂肪质量的损失与老年人的 MCI 相关。我们还发现，四肢肌肉质量与男性的 MCI 更密切相关，而与女性的 MCI 相关性较低。这些结果表明，四肢肌肉质量与 MCI 之间的关联可能基于性别具有不同的潜在机制。老年医学与老年病学杂志 2017 年；17：2053-2059。
