Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Graduate School of Human Development and Environment, Kobe University, Nada-ku, Kobe, Japan.
J Alzheimers Dis. 2017;60(3):913-921. doi: 10.3233/JAD-161230.
The associations between components of metabolic syndrome (MetS) and mild cognitive impairment (MCI) subtypes remain unclear.
The study aim was to identify the prevalence of MetS for MCI subtypes and to investigate sex differences in the association between MetS and MCI subtypes in older Japanese adults.
The study analyzed data from 3,312 men and women aged 70 years or more. MetS was diagnosed according to International Diabetes Federation criteria. Participants completed cognitive tests and were categorized into normal cognition, amnestic MCI (aMCI), and non-amnestic MCI (naMCI). The associations between MetS and its components and MCI subtypes were analyzed using multiple logistic regression.
MetS prevalence was greater in participants with naMCI (men: p = 0.030; women: p = 0.040). Participants with naMCI showed higher odds ratios (OR) of MetS (men: 2.45, 95% confidence intervals (CI): 1.13-5.32; women: OR: 1.94, 95% CI: 1.12-3.39) compared with participants with normal cognition. MetS was not associated with aMCI. Analysis of MetS components showed that raised glucose (OR: 1.62, 95% CI: 1.19-2.22) and reduced high-density lipoprotein cholesterol (OR: 1.97, 95% CI: 1.25-3.12) were associated with naMCI in men. In women, raised blood pressure (OR: 1.42, 95% CI: 1.03-1.94) and raised glucose (OR: 1.32, 95% CI: 1.02-1.71) were associated with naMCI.
MetS was associated only with naMCI regardless of sex, which suggests etiologic differences in MCI subtypes. We also found sex differences in the relationship between naMCI risk and MetS and its components.
代谢综合征（MetS）各组分与轻度认知障碍（MCI）各亚型之间的关联尚不清楚。
本研究旨在确定 MCI 各亚型中 MetS 的患病率，并探讨老年日本成年人中 MetS 与 MCI 各亚型之间关联的性别差异。
本研究分析了 3312 名年龄在 70 岁及以上的男性和女性的数据。根据国际糖尿病联合会标准诊断 MetS。参与者完成认知测试，并分为正常认知、遗忘型 MCI（aMCI）和非遗忘型 MCI（naMCI）。使用多因素逻辑回归分析 MetS 及其各组分与 MCI 各亚型之间的关联。
naMCI 组参与者的 MetS 患病率更高（男性：p=0.030；女性：p=0.040）。与正常认知组相比，naMCI 组参与者的 MetS 发生比更高（男性：2.45，95%置信区间[CI]：1.13-5.32；女性：OR：1.94，95% CI：1.12-3.39）。MetS 与 aMCI 无关。MetS 组分分析显示，男性中升高的血糖（OR：1.62，95% CI：1.19-2.22）和降低的高密度脂蛋白胆固醇（OR：1.97，95% CI：1.25-3.12）与 naMCI 相关。在女性中，升高的血压（OR：1.42，95% CI：1.03-1.94）和升高的血糖（OR：1.32，95% CI：1.02-1.71）与 naMCI 相关。
无论性别如何，MetS 仅与 naMCI 相关，这表明 MCI 各亚型的病因学存在差异。我们还发现 naMCI 风险与 MetS 及其各组分之间的关系存在性别差异。
