Raina Rupesh, Herrera Nicholas, Krishnappa Vinod, Sethi Sidharth Kumar, Deep Akash, Kao Wei-Ming, Bunchman Timothy, Abu-Arja Rolla
Department of Pediatric Nephrology, Akron Children's Hospital, Akron, OH, USA.
Department of Pediatrics-Nephrology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Pediatr Transplant. 2017 Jun;21(4). doi: 10.1111/petr.12935.
AKI in the setting of HSCT is commonly investigated among adult patients. In the same way, malignancies requiring treatment with HSCT are not limited to the adult patient population, AKI following HSCT is frequently encountered within pediatric patient populations. However, inadequate information regarding epidemiology and pathophysiology specific to pediatric patients prevents development of appropriate and successful therapeutic strategies for those afflicted. Addressing AKI in the context of sinusoidal obstruction syndrome, chemotherapy, thrombotic microangiopathy and hypertension post chemotherapy, glomerulonephritis, and graft versus host disease provides greater insight into renal impairment associated with these HSCT-related ailments. To obtain a better understanding of AKI among pediatric patients receiving HSCT, we investigated the current literature specifically addressing these areas of concern.
造血干细胞移植（HSCT）背景下的急性肾损伤（AKI）通常在成年患者中进行研究。同样，需要进行HSCT治疗的恶性肿瘤并不局限于成年患者群体，儿科患者群体中也经常出现HSCT后的AKI。然而，关于儿科患者特有的流行病学和病理生理学信息不足，阻碍了为这些患者制定适当且成功的治疗策略。在肝窦阻塞综合征、化疗、化疗后血栓性微血管病和高血压、肾小球肾炎以及移植物抗宿主病的背景下探讨AKI，能更深入地了解与这些HSCT相关疾病相关的肾功能损害。为了更好地了解接受HSCT的儿科患者中的AKI，我们专门研究了针对这些关注领域的现有文献。
