Wang Zi-Sai, Wang Sheng-Feng, Zhao Ming-Yi, He Qing-Nan
Department of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China(He Q-N, Email:
Zhongguo Dang Dai Er Ke Za Zhi. 2024;26(9):1002-1008. doi: 10.7499/j.issn.1008-8830.2401011.
Glomerular filtration rate (GFR) is a critical indicator of renal function assessment, which exhibits age-dependency in children and may differ from adults under various disease conditions. In recent years, there has been a growing focus on GFR among scholars, with an increasing number of clinical studies dedicated to refining and optimizing GFR estimation to span all pediatric age groups. However, the methods and assessment equations for estimating GFR may vary under different disease conditions, affecting the accuracy and applicability of assessments. This article reviews the peculiarities of renal function in children, explores GFR measurement methods, and evaluates the application of various GFR assessment equations in pediatric clinical practice, providing a reference for clinical assessment of renal function in children.
肾小球滤过率（GFR）是评估肾功能的关键指标，在儿童中呈现出年龄依赖性，并且在各种疾病状态下可能与成人有所不同。近年来，学者们对GFR的关注日益增加，越来越多的临床研究致力于完善和优化GFR估计方法，以涵盖所有儿科年龄组。然而，在不同疾病状态下，估计GFR的方法和评估方程可能会有所不同，从而影响评估的准确性和适用性。本文综述了儿童肾功能的特点，探讨了GFR测量方法，并评估了各种GFR评估方程在儿科临床实践中的应用，为儿童肾功能的临床评估提供参考。
