Watanabe K, Tanaka T, Yamamoto I, Yoshimura H
Department of Hygienic Chemistry, School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Biochem Biophys Res Commun. 1988 Nov 30;157(1):75-80. doi: 10.1016/s0006-291x(88)80013-5.
Brain microsomes of mice, rats, guinea pigs and rabbits catalyzed the oxidation of delta 8- and delta 9-tetrahydrocannabinol to their monohydroxylated metabolites. The most prominent metabolite was the 4'-hydroxylated metabolite on the pentyl side chain of the cannabinoids in all species tested, except that the 5'-hydroxylation of delta 9-tetrahydrocannabinol was most abundant in the guinea pig. These results are quite different from the metabolic profile of the cannabinoids with hepatic microsomes.
小鼠、大鼠、豚鼠和兔子的脑微粒体催化了δ8-和δ9-四氢大麻酚氧化为它们的单羟基化代谢产物。在所测试的所有物种中，最主要的代谢产物是大麻素戊基侧链上的4'-羟基化代谢产物，但豚鼠中δ9-四氢大麻酚的5'-羟基化最为丰富。这些结果与大麻素在肝微粒体中的代谢概况有很大不同。
