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Microsomal oxygenase catalyzed oxidation of 11-hydroxy-delta 8-tetrahydrocannabinol to 11-oxo-delta 8-tetrahydrocannabinol.

作者信息

Watanabe K, Yamamoto I, Oguri K, Yoshimura H

出版信息

Biochem Biophys Res Commun. 1979 May 14;88(1):178-82. doi: 10.1016/0006-291x(79)91713-3.

DOI:10.1016/0006-291x(79)91713-3
PMID:36896
Abstract
摘要

相似文献

1
Microsomal oxygenase catalyzed oxidation of 11-hydroxy-delta 8-tetrahydrocannabinol to 11-oxo-delta 8-tetrahydrocannabinol.微粒体加氧酶催化11-羟基-δ8-四氢大麻酚氧化为11-氧代-δ8-四氢大麻酚。
Biochem Biophys Res Commun. 1979 May 14;88(1):178-82. doi: 10.1016/0006-291x(79)91713-3.
2
Characterization of microsomal alcohol oxygenase catalyzing the oxidation of 7-hydroxy-delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol in rat liver.大鼠肝脏中催化7-羟基-δ8-四氢大麻酚氧化为7-氧代-δ8-四氢大麻酚的微粒体乙醇氧化酶的特性研究
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3
CYP3A4 is a major isoform responsible for oxidation of 7-hydroxy-Delta(8)-tetrahydrocannabinol to 7-oxo-delta(8)-tetrahydrocannabinol in human liver microsomes.细胞色素P450 3A4（CYP3A4）是一种主要的同工酶，负责在人肝微粒体中将7-羟基-Δ⁸-四氢大麻酚氧化为7-氧代-Δ⁸-四氢大麻酚。
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4
Catalytic activity of cytochrome P450 isozymes purified from rat liver in converting 11-oxo-delta 8-tetrahydrocannabinol to delta 8-tetrahydrocannabinol-11-oic acid.
Biochem Pharmacol. 1991 Aug 22;42(6):1255-9. doi: 10.1016/0006-2952(91)90262-4.
5
Effective NADH-dependent oxidation of 7beta-hydroxy-delta8-tetrahydrocannabinol to the corresponding ketone by Japanese monkey hepatic microsomes.日本猕猴肝微粒体将7β-羟基-δ8-四氢大麻酚有效氧化为相应酮类的NADH依赖性反应。
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6
Microsomal alcohol oxygenase: purification and characterization of a cytochrome P450 responsible for oxidation of 7-hydroxy-delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol in guinea pig liver.微粒体乙醇氧化酶：豚鼠肝脏中负责将7-羟基-δ8-四氢大麻酚氧化为7-氧代-δ8-四氢大麻酚的细胞色素P450的纯化及特性研究
Arch Biochem Biophys. 1997 Dec 1;348(1):56-64. doi: 10.1006/abbi.1997.0390.
7
Monkey hepatic microsomal alcohol oxygenase: purification and characterization of a cytochrome P450 enzyme catalyzing the stereoselective oxidation of 7alpha- and 7beta-hydroxy-delta8-tetrahydrocannabinol to 7-oxo-delta8-tetrahydrocannabinol.猴肝微粒体乙醇氧化酶：一种催化7α-和7β-羟基-δ8-四氢大麻酚立体选择性氧化为7-氧代-δ8-四氢大麻酚的细胞色素P450酶的纯化与特性研究
Biol Pharm Bull. 2002 Jan;25(1):42-7. doi: 10.1248/bpb.25.42.
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8 alpha, 9 alpha-Epoxyhexahydrocannabinol formation from delta 8-tetrahydrocannabinol by mouse liver microsomes.
Biochem Biophys Res Commun. 1982 Dec 15;109(3):922-6. doi: 10.1016/0006-291x(82)92028-9.
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Spectral interaction of 11-hydroxy-delta-8-tetrahydrocannabinol with rabbit and rat liver microsomal cytochrome P-450.11-羟基-δ-8-四氢大麻酚与兔和大鼠肝微粒体细胞色素P-450的光谱相互作用。
Chem Pharm Bull (Tokyo). 1980 Jun;28(6):1939-42. doi: 10.1248/cpb.28.1939.
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Mechanism of hepatic microsomal oxidation of 11-hydroxy-delta 8-tetrahydrocannabinol to 11-oxo-delta 8-tetrahydrocannabinol. Evidence for hydration of the aldehyde formed.
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NAD(P)-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite.烟酰胺腺嘌呤二核苷酸（磷酸）依赖性醇氧化还原酶将7-羟基大麻二酚氧化为一种具有反应活性的甲酰代谢物。
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