Lin X, Lin M, Wei X, Chen Q
Department of Oncology, Fujian Provincial Hospital, Fuzhou, Fujian, PR China.
Department of Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, PR China.
Indian J Cancer. 2016 Oct-Dec;53(4):499-504. doi: 10.4103/0019-509X.204782.
PURPOSES/OBJECTIVES: By observing and analyzing the clinical features of the colon cancer and the influence factors of liver metastasis, we try to find out independent risk factors with significant influence on colon cancer liver metastasis as well as to provide reference for clinical treatment.
A total of 306 cases of colon cancer patients' clinical data, including gender, age, primary focal size, primary focal intestinal segment, degree of differentiation, infiltration depth, level of serum carcinoembryonic antigen (CEA) before surgery, lymph node metastasis, liver basic diseases were collected and recorded. Single-factor Chi-square analysis and multifactor logistic regression analysis (SPSS 16.0 software) were used to retrospectively study the possible influence factors of colon liver metastases and to preliminary discuss the potential risk factors of liver metastasis in colon cancer patients.
The Chi-square analysis showed that patients' primary focal segment, degree of differentiation, infiltration depth, level of serum CEA before surgery, and states of hepatitis B does 2 half-and-half had significant effect on the incidence of liver metastasis. However, in the further logistic regression analysis, it showed that only the infiltration depth and the states of hepatitis B does 2 half-and-half were the independent risk factors that influence the hepatic metastases. What was more, the both subgroups of positive hepatitis B with infection and vaccine showed significant statistical differences when comparing with hepatitis B all negative in the event of the probability of liver metastases (P = 0.011 and 0.004).
The infiltration depth and the states of hepatitis B does 2 half-and-half were the independent risk factors on colon cancer patients' hepatic metastases. Those with the infiltration depth of T4 had a higher rate of hepatic metastases. Patients with does 2 half-and-half-positive hepatitis B (whether subgroup of hepatitis B virus infection or subgroup hepatitis B vaccine related) had a lower incidence rate of liver metastasis than those with hepatitis B all negative.
目的/目标：通过观察和分析结肠癌的临床特征及肝转移的影响因素，试图找出对结肠癌肝转移有显著影响的独立危险因素，为临床治疗提供参考。
收集并记录306例结肠癌患者的临床资料，包括性别、年龄、原发灶大小、原发灶肠段、分化程度、浸润深度、术前血清癌胚抗原（CEA）水平、淋巴结转移、肝脏基础疾病。采用单因素卡方分析和多因素logistic回归分析（SPSS 16.0软件），回顾性研究结肠癌肝转移的可能影响因素，并初步探讨结肠癌患者肝转移的潜在危险因素。
卡方分析显示，患者的原发灶肠段、分化程度、浸润深度、术前血清CEA水平以及乙肝“大二阳”状态对肝转移发生率有显著影响。然而，进一步的logistic回归分析表明，只有浸润深度和乙肝“大二阳”状态是影响肝转移的独立危险因素。此外，在肝转移概率方面，乙肝感染阳性和疫苗接种阳性这两个亚组与乙肝全阴性相比均有显著统计学差异（P = 0.011和0.004）。
浸润深度和乙肝“大二阳”状态是结肠癌患者肝转移的独立危险因素。浸润深度为T4的患者肝转移率较高。乙肝“大二阳”阳性患者（无论是乙肝病毒感染亚组还是乙肝疫苗相关亚组）的肝转移发生率低于乙肝全阴性患者。
