Qian Hong-Gang, Hao Chun-Yi
Hepatogastroenterology. 2014 Oct;61(135):1908-14.
BACKGROUND/AIMS: The relationships between Hepatitis B virus infection, cirrhosis and colorectal cancer liver metastasis have not been investigated simultaneously and it remained unclear that whether the immune changes caused by Hepatitis B virus infection or the structural changes caused by cirrhosis conduce to the lower incidence of liver metastasis.
Data of 1413 colorectal cancer patients were reviewed to investigate the impacts of Hepatitis B virus infection and cirrhosis on the occurrence and prognosis of liver metastasis.
The incidence of liver metastasis in the Hepatitis B virus infection group or in the cirrhotic group was lower than the control groups (9.4% vs 23.9%, P<0.001; 6.3% vs 22.9%, P=0.03, respectively). However, a multivariate logistic regression analysis showed that only Hepatitis B virus, the T and N classifications were independent factors for the occurrence of liver metastasis in colorectal cancer. There was no statistically significant difference in 5-years survival rates between hepatitis B virus infection group and the non-infection group, nor between cirrhotic group and non-cirrhosis group (P>0.05).
Hepatitis B virus infection was one of the independent factors for the occurrence of liver metastasis in colorectal cancer but not for the survival.
背景/目的：乙型肝炎病毒感染、肝硬化与结直肠癌肝转移之间的关系尚未同时进行研究，目前仍不清楚是乙型肝炎病毒感染引起的免疫变化还是肝硬化引起的结构变化导致肝转移发生率较低。
回顾1413例结直肠癌患者的数据，以研究乙型肝炎病毒感染和肝硬化对肝转移发生及预后的影响。
乙型肝炎病毒感染组或肝硬化组的肝转移发生率低于对照组（分别为9.4%对23.9%，P<0.001；6.3%对22.9%，P=0.03）。然而，多因素逻辑回归分析显示，仅乙型肝炎病毒、T和N分类是结直肠癌肝转移发生的独立因素。乙型肝炎病毒感染组与非感染组之间、肝硬化组与非肝硬化组之间的5年生存率无统计学显著差异（P>0.05）。
乙型肝炎病毒感染是结直肠癌肝转移发生的独立因素之一，但不是生存的独立因素。
