铜催化炔烃、炔基羧酸和乙烯基羧酸与氟代烷基卤化物的氟烷基化反应。
Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides.
作者信息
Ma Jing-Jing, Yi Wen-Bin
机构信息
School of Chemical Engineering, Nanjing University of Science and Technology, Xiao Ling Wei Street, Nanjing 210094, People's Republic of China.
出版信息
Org Biomol Chem. 2017 May 23;15(20):4295-4299. doi: 10.1039/c7ob00641a.
PMID:28485458
Abstract
Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group tolerance and excellent regio- and stereoselectivities. A variety of fluoroalkyl halides including ethyl bromodifluoroacetate can be employed. Additionally, an unprecedented decarboxylative fluoroalkylation of α, β-unsaturated carboxylic acids has been achieved via a radical pathway.
摘要
铜催化的炔烃和炔基羧酸的氟烷基化反应已实现，具有高官能团耐受性以及出色的区域和立体选择性。可以使用包括溴二氟乙酸乙酯在内的多种氟代烷基卤化物。此外，通过自由基途径实现了α,β-不饱和羧酸前所未有的脱羧氟烷基化反应。
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