Wenger T, Croix D, Tramu G
2nd Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.
Biol Reprod. 1988 Oct;39(3):540-5. doi: 10.1095/biolreprod39.3.540.
The effect of the main psychoactive component of marihuana, delta-9-tetrahydrocannabinol (THC) was investigated on the onset of puberty and on the reproductive function in female rats up to the seventy-fifth to eightieth day of life. The drug was administered i.p. at a dose of 1 microgram/kg/day between the twenty-second postnatal day and the day of vaginal opening (V.O.). The administration of THC caused a 2-day delay in V. O., and the number of ova on the day of first estrus was significantly lower in treated rats than in controls. No differences were observed in serum gonadotropin and prolactin (PRL) levels on the day of V. O. After puberty, alterations occurred in the neuroendocrine functions of animals receiving THC that persisted until adulthood: estrous cycles were irregular, the number of ova in animals killed 35-40 days after V. O. was reduced, and serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were decreased (diminution of serum FSH content was less expressed). An increase in serum PRL concentration could be demonstrated only in animals killed on the day of estrus. From these results, it might be concluded that THC administered to prepubertal rats--even in a very low dose--causes long-term irreversible alterations in reproductive functions. The importance of the fight against drug abuse is emphasized.
研究了大麻的主要精神活性成分Δ⁹-四氢大麻酚（THC）对雌性大鼠青春期启动及直至出生后第75至80天的生殖功能的影响。在出生后第22天至阴道开口（V.O.）之日期间，以1微克/千克/天的剂量腹腔注射该药物。THC的给药使阴道开口延迟了2天，并且在首次发情之日，受试大鼠的卵子数量显著低于对照组。在阴道开口之日，血清促性腺激素和催乳素（PRL）水平未观察到差异。青春期后，接受THC的动物的神经内分泌功能出现改变，这些改变持续至成年期：发情周期不规则，在阴道开口后35 - 40天处死的动物的卵子数量减少，血清黄体生成素（LH）和促卵泡激素（FSH）水平降低（血清FSH含量的降低不太明显）。仅在发情之日处死的动物中可证明血清PRL浓度升高。从这些结果可以得出结论，给青春期前大鼠施用THC——即使是非常低的剂量——也会导致生殖功能长期不可逆的改变。强调了打击药物滥用的重要性。
