Wenger T, Croix D, Tramu G, Leonardelli J
2eme Laboratoire d'Anatomie, Faculté de Médecine, Budapest, Hongrie.
Ann Endocrinol (Paris). 1992;53(1):37-43.
The main psychoactive component of marihuana, delta-9-tetrahydrocannabiol (THC), was investigated at low doses (1 microgram/kg/day) on the onset of puberty, on the reproductive functions in female rats up to the seventy fifth to eightieth day of life as well as during the pregnancy. The administration of THC caused a delay of the onset of puberty, and the number of ova on the day of first estrus was significantly lower in treated animals. After puberty, alterations occurred in the neuroendocrine functions of animals received THC: estrous cycles were irregular, serum LH level was decreased. When THC was injected during the third week of pregnancy it caused a significant prolongation of the gestation period. There was 30% stillbirths (v.s. 3% in physiological saline treated rats). No teratological effects were observed. Serum LH, progesterone and prostaglandin contents were decreased. The results indicate that marihuana causes alterations in reproductive functions. The importance of fight against drug abuse is emphasized.
研究了大麻的主要精神活性成分Δ-9-四氢大麻酚（THC）在低剂量（1微克/千克/天）时对青春期开始、雌性大鼠直至生命的第七十五至八十天以及怀孕期间生殖功能的影响。给予THC导致青春期开始延迟，且在首次发情日，受试动物的卵子数量显著减少。青春期后，接受THC的动物神经内分泌功能出现改变：发情周期不规则，血清促黄体生成素（LH）水平降低。在怀孕第三周注射THC会导致妊娠期显著延长。死产率为30%（生理盐水处理的大鼠为3%）。未观察到致畸作用。血清LH、孕酮和前列腺素含量降低。结果表明，大麻会导致生殖功能改变。强调了打击药物滥用的重要性。
