合并队列中的血压、心率和双乘积：日本动脉粥样硬化纵向研究

Blood pressure, heart rate, and double product in a pooled cohort: the Japan Arteriosclerosis Longitudinal Study.

作者信息

Asayama Kei, Hozawa Atsushi, Taguri Masataka, Ohkubo Takayoshi, Tabara Yasuharu, Suzuki Kazuo, Ando Takashi, Harada Akiko, Ohashi Yasuo, Ueshima Hirotsugu, Toyoshima Hideaki, Imai Yutaka

机构信息

aDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo bDepartment of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences cDepartment of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai dDepartment of Biostatistics, Graduate School of Medicine, Yokohama City University, Yokohama eCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto fHonjo Daiichi Hospital, Yurihonjo gSchool of Medicine, University of Tsukuba, Tsukuba hDepartment of Integrated Science and Engineering for Sustainable Society, Faculty of Science and Engineering, Chuo University, Tokyo iCenter for Epidemiologic Research in Asia and Department of Public Health, Shiga University of Medical Science, Otsu jEducation and Clinical Research Training Center, Anjo Kosei Hospital, Anjo, Japan.

出版信息

J Hypertens. 2017 Sep;35(9):1808-1815. doi: 10.1097/HJH.0000000000001399.

DOI:10.1097/HJH.0000000000001399

PMID:28486272

Abstract

OBJECTIVE

To identify the characteristics of blood pressure (BP), heart rate (HR), and double product in a Japanese population sample.

METHODS

We pooled individual records from 1999 to 2005 for 111 007 participants in 25 community-based cohorts and seven worksite-based cohorts. The data were analyzed to provide information on BP, HR, and double product according to age-sex groups and use of antihypertensive medication.

RESULTS

Average BP was 130/77 mmHg among men and women combined. Among untreated individuals, SBP increased with age, whereas DBP reached a ceiling around the age of 60 years. The average SBP of treated participants was around 140 mmHg, irrespective of age, whereas DBP decreased linearly with age, and 56.4% of treated participants had a BP of 140/90 mmHg or over. HR did not differ across age groups or treatment status. The double product, also called the rate-pressure product, calculated by multiplying the SBP and the HR, increased with age among untreated individuals, whereas it first decreased and then increased with age among treated individuals.

CONCLUSION

Based on these collaborative data, insufficient BP control in Japan, where the average life expectancy is the longest in the world, was seen.

摘要

目的

确定日本人群样本中血压（BP）、心率（HR）及双乘积的特征。

方法

我们汇总了1999年至2005年期间25个社区队列和7个工作场所队列中111007名参与者的个人记录。对数据进行分析，以提供按年龄性别分组及使用降压药物情况的血压、心率和双乘积信息。

结果

男性和女性的平均血压为130/77 mmHg。在未接受治疗的个体中，收缩压随年龄增长而升高，而舒张压在60岁左右达到峰值。接受治疗的参与者的平均收缩压约为140 mmHg，与年龄无关，而舒张压随年龄呈线性下降，56.4%接受治疗的参与者血压为140/90 mmHg或更高。心率在不同年龄组或治疗状态之间没有差异。双乘积，也称为速率压力乘积，通过收缩压与心率相乘计算得出，在未接受治疗的个体中随年龄增长而增加，而在接受治疗的个体中则先下降后随年龄增长而增加。