Nosrati Mina, Nikbakht-Jam Irandokht, Eslami Saeid, Khademi Mohammad M, Foroutan-Tanha Mojtaba, Hadizadeh Farzin, Sahebkar Amir H, Tavallaie Shima, Taherzadeh Zhila, Ghayour-Mobarhan Majid, Ferns Gordon A A
Biochemistry and Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Clin Pharmacol. 2017;12(2):113-121. doi: 10.2174/1574884712666170509162523.
Recent studies have shown that antibody titers to heat shock protein 27 (anti-Hsp27) and serum hs-CRP concentrations are elevated in patients with MetS, and may be associated with an increased risk of cardiovascular disease. Crocin is a natural carotenoid with cardio protective effects.
Because of the previous evidence for the beneficial effects of saffron in patients with MetS, this study investigated the effect of supplementation with crocin, the active ingredient of saffron, on serum anti-Hsp27 and hs-CRP in patients with MetS.
Sixty subjects with metabolic syndrome were randomized to receive crocin (n=30, 15 mg twice a day) or placebo (n=30, twice a day) for a duration of eight weeks. At the end of study, serum anti-Hsp27 and hs-CRP concentrations were measured and compared between the groups.
Serum anti-Hsp27 titers fell by 13% (p>0.05) in the crocin group but it rose in the placebo group by 22% (p>0.05). The magnitude of change in serum anti-Hsp27 titers was not significantly different between the study groups (p = 0.28). In the crocin group, serum anti-Hsp27 changes had a borderline negative correlation with glucose (r= -0.35, p=0.06) and a positive correlation with waist circumference (r=0.39, p=0.035). Serum hs-CRP levels were significantly reduced in both groups but these reductions were not significantly different between the study groups (p = 0.31).
There was no significant effect of crocin on serum anti-Hsp27 titers in subjects with MetS, but this needs further confirmation in larger-scale trials.
近期研究表明，代谢综合征（MetS）患者体内热休克蛋白27抗体滴度（抗Hsp27）和血清超敏C反应蛋白（hs-CRP）浓度升高，且可能与心血管疾病风险增加有关。藏红花素是一种具有心脏保护作用的天然类胡萝卜素。
鉴于此前有证据表明藏红花对MetS患者有益，本研究调查了补充藏红花的活性成分藏红花素对MetS患者血清抗Hsp27和hs-CRP的影响。
60名代谢综合征患者被随机分为两组，一组接受藏红花素（n = 30，每天两次，每次15毫克），另一组接受安慰剂（n = 30，每天两次），为期8周。研究结束时，测量并比较两组患者血清抗Hsp27和hs-CRP浓度。
藏红花素组血清抗Hsp27滴度下降了13%（p>0.05），而安慰剂组上升了22%（p>0.05）。两组间血清抗Hsp27滴度变化幅度无显著差异（p = 0.28）。在藏红花素组中，血清抗Hsp27变化与血糖呈边缘负相关（r = -0.35，p = 0.06），与腰围呈正相关（r = 0.39，p = 0.035）。两组血清hs-CRP水平均显著降低，但两组间降低幅度无显著差异（p = 0.31）。
藏红花素对MetS患者血清抗Hsp27滴度无显著影响，但这需要在更大规模试验中进一步证实。
