Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Curr Neuropharmacol. 2018;16(1):5-16. doi: 10.2174/1570159X15666170509101237.
Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our understanding of this relationship remains unclear.
The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non rapid eye movement sleep and idiopathic generalized epilepsy share the same thalamocortical networks. Most of neurotransmitters and neuromodulators such as adenosine, melatonin, prostaglandin D2, serotonin, and histamine are found to regulate the sleep-wake behavior and also considered to have antiepilepsy effects; antiepileptic drugs, in turn, also have effects on sleep. Furthermore, many drugs that regulate the sleep-wake cycle can also serve as potential antiseizure agents. The nonpharmacological management of epilepsy including ketogenic diet, epilepsy surgery, neurostimulation can also influence sleep.
In this paper, we address the issues involved in these phenomena and also discuss the various therapies used to modify them.
睡眠与癫痫以复杂的双向方式相互关联。然而，我们对这种关系的理解仍不清楚。
有关睡眠与癫痫相互作用的神经生物学基础的文献表明，非快速眼动睡眠和特发性全面性癫痫共享相同的丘脑皮质网络。大多数神经递质和神经调质，如腺苷、褪黑素、前列腺素 D2、血清素和组胺，被发现调节睡眠-觉醒行为，也被认为具有抗癫痫作用；抗癫痫药物反过来也对睡眠有影响。此外，许多调节睡眠-觉醒周期的药物也可以作为潜在的抗癫痫药物。包括生酮饮食、癫痫手术、神经刺激在内的癫痫非药物管理也可以影响睡眠。
在本文中，我们讨论了这些现象中涉及的问题，并讨论了用于改变这些问题的各种治疗方法。
