Li Zi-Yuan, Qin Xiao-Ya, Guo Li-Ying, Wang Huan, Liu Xiao-Xin, Zheng Zhuo-Zhao, Guan Hai-Tao, Song Li, Zou Ying-Hua, Fan Tian-Yuan
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital, Beijing 100044, China.
Int J Pharm. 2017 Jul 15;527(1-2):31-41. doi: 10.1016/j.ijpharm.2017.04.069. Epub 2017 May 6.
To develop embolic microspheres with MRI detectability, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized and mixed with monomer of acrylic acid to prepare SPIONs-loaded polymerized microspheres (SPMs) by inverse suspension polymerization method. The SPMs were evaluated for the ability of embolization by investigating the morphology, particle size, elasticity and renal arterial embolization to rabbits. Meanwhile, the loading of SPIONs was verified by optical microscope, transmission electron microscope, Fourier transform infrared spectrum, vibrating sample magnetometer, X-ray diffraction and X-ray photoelectron spectroscopy, and the content of SPIONs in SPMs was measured quantitatively. Furthermore, the MRI detectability of SPMs was testified in gel phantom, mice and rabbits respectively by a clinical 3.0T MRI scanner. The results revealed the SPMs were potential MRI detectable embolic microspheres for improving the effectiveness and safety of embolotherapy in the future.
为了开发具有MRI可检测性的栓塞微球，合成了超顺磁性氧化铁纳米颗粒（SPIONs），并将其与丙烯酸单体混合，通过反相悬浮聚合法制备了负载SPIONs的聚合微球（SPMs）。通过研究SPMs的形态、粒径、弹性以及对兔肾动脉的栓塞情况，评估其栓塞能力。同时，通过光学显微镜、透射电子显微镜、傅里叶变换红外光谱、振动样品磁强计、X射线衍射和X射线光电子能谱对SPIONs的负载情况进行验证，并对SPMs中SPIONs的含量进行定量测定。此外，分别通过临床3.0T MRI扫描仪在凝胶体模、小鼠和兔体内验证了SPMs的MRI可检测性。结果表明，SPMs有望成为未来提高栓塞治疗有效性和安全性的具有MRI可检测性的栓塞微球。
