应激过程中，无规则蛋白适应性地重新组织细胞物质。
Intrinsically Disordered Proteins Adaptively Reorganize Cellular Matter During Stress.
机构信息
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
出版信息
Trends Biochem Sci. 2017 Jun;42(6):410-412. doi: 10.1016/j.tibs.2017.04.007. Epub 2017 May 6.
PMID:28487210
Abstract
Intrinsically disordered proteins (IDPs) can protect cells from diverse stresses by forming higher order assemblies such as reversible aggregates or granules. Recently, Boothby et al. show that IDPs protect tardigrades against desiccation by forming a glass-like amorphous matrix, highlighting that material properties of disordered proteins can confer adaptation during stress.
摘要
无规则蛋白（IDPs）可以通过形成更高阶的组装体，如可逆聚集体或颗粒，来保护细胞免受各种压力的影响。最近，Boothby 等人表明，IDPs 通过形成玻璃状无定形基质来保护缓步动物免受干燥的影响，这强调了无规则蛋白的物质特性可以在压力下赋予适应性。
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