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一种常见气味结合蛋白基因的变异与人类的苦味敏感性相关。

Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people.

作者信息

Tomassini Barbarossa Iole, Ozdener M Hakan, Love-Gregory Latisha, Mitreva Makedonka, Abumrad Nada A, Pepino M Yanina

机构信息

University of Cagliari, Monserrato, CA, I 09042, Italy.

Monell Center, Philadelphia, PA, 19130, USA.

出版信息

Behav Brain Res. 2017 Jun 30;329:200-204. doi: 10.1016/j.bbr.2017.05.015. Epub 2017 May 6.

DOI:10.1016/j.bbr.2017.05.015
PMID:28487220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5534261/
Abstract

Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.

摘要

深入了解人类苦味感知背后的信号传导机制对于设计新型有效的苦味阻滞剂至关重要，这类阻滞剂可改善营养状况并提高对口服苦味药物的依从性。在此，我们表明人类气味结合蛋白基因OBPIIa的变异性与个体对脂肪（油酸）和典型苦味刺激物6-正丙基硫氧嘧啶（PROP）的苦味感知差异相关，这表明在调节苦味敏感性方面存在一种新的嗅觉作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e5/5534261/fa40d5a285ed/nihms876908f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e5/5534261/60fecdaef815/nihms876908f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e5/5534261/fa40d5a285ed/nihms876908f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e5/5534261/60fecdaef815/nihms876908f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e5/5534261/fa40d5a285ed/nihms876908f2.jpg

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2
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PLoS One. 2015 Jun 23;10(6):e0131104. doi: 10.1371/journal.pone.0131104. eCollection 2015.
3
Bitter and sweet taste receptors regulate human upper respiratory innate immunity.
涉及帕金森病嗅觉和味觉减退的分子和遗传因素及其与微生物组的关联。
Int J Mol Sci. 2021 Apr 20;22(8):4286. doi: 10.3390/ijms22084286.
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Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene.炎症性肠病（IBD）患者的嗅觉功能与其体重指数和气味结合蛋白（OBPIIa）基因多态性有关。
Nutrients. 2021 Feb 22;13(2):703. doi: 10.3390/nu13020703.
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