杀虫剂暴露与肥胖症和2型糖尿病发生发展之间的潜在关联。
Potential contribution of insecticide exposure and development of obesity and type 2 diabetes.
作者信息
Xiao Xiao, Clark John M, Park Yeonhwa
机构信息
Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst 01003, MA, USA.
出版信息
Food Chem Toxicol. 2017 Jul;105:456-474. doi: 10.1016/j.fct.2017.05.003. Epub 2017 May 6.
Abstract
The introduction of insecticides has greatly improved agricultural productivity and human nutrition; however, the wide use of insecticides has also sparked growing concern over their health impacts. Increased rate of cancers, neurodegenerative disorders, reproductive dysfunction, birth defects, respiratory diseases, cardiovascular diseases and aging have been linked with insecticide exposure. Meanwhile, a growing body of evidence is suggesting that exposure to insecticides can also potentiate the risk of obesity and type 2 diabetes. This review summarizes the relationship between insecticide exposure and development of obesity and type 2 diabetes using epidemiological and rodent animal studies, including potential mechanisms. The evidence as a whole suggests that exposure to insecticides is linked to increased risk of obesity and type 2 diabetes.
摘要
杀虫剂的引入极大地提高了农业生产力和人类营养水平；然而，杀虫剂的广泛使用也引发了人们对其健康影响的日益关注。癌症、神经退行性疾病、生殖功能障碍、出生缺陷、呼吸系统疾病、心血管疾病和衰老发生率的增加都与接触杀虫剂有关。与此同时，越来越多的证据表明，接触杀虫剂还会增加肥胖和2型糖尿病的风险。本综述利用流行病学和啮齿动物研究总结了接触杀虫剂与肥胖和2型糖尿病发生之间的关系，包括潜在机制。总体证据表明，接触杀虫剂与肥胖和2型糖尿病风险增加有关。
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本文引用的文献
1
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Toxicol Rep. 2014 Aug 20;1:554-561. doi: 10.1016/j.toxrep.2014.08.004. eCollection 2014.
2
Deltamethrin increases the fat accumulation in 3T3-L1 adipocytes and Caenorhabditis elegans.溴氰菊酯增加了3T3-L1脂肪细胞和秀丽隐杆线虫中的脂肪积累。
Food Chem Toxicol. 2017 Mar;101:149-156. doi: 10.1016/j.fct.2017.01.015. Epub 2017 Jan 22.
3
Imidacloprid Promotes High Fat Diet-Induced Adiposity and Insulin Resistance in Male C57BL/6J Mice.吡虫啉促进雄性C57BL/6J小鼠的高脂饮食诱导肥胖和胰岛素抵抗。
J Agric Food Chem. 2016 Dec 14;64(49):9293-9306. doi: 10.1021/acs.jafc.6b04322. Epub 2016 Dec 5.
4
4,4'-Dichlorodiphenyltrichloroethane (DDT) and 4,4'-dichlorodiphenyldichloroethylene (DDE) promote adipogenesis in 3T3-L1 adipocyte cell culture.4,4'-二氯二苯三氯乙烷（DDT）和4,4'-二氯二苯二氯乙烯（DDE）在3T3-L1脂肪细胞培养中促进脂肪生成。
Pestic Biochem Physiol. 2016 Jul;131:40-5. doi: 10.1016/j.pestbp.2016.01.005. Epub 2016 Jan 20.
5
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Food Chem Toxicol. 2016 Jun;92:217-23. doi: 10.1016/j.fct.2016.04.011. Epub 2016 Apr 19.
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8
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10
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