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[适应寒冷环境的大鼠在深度冷却过程中α2 - 和β1 - 肾上腺素能反应系统敏感性的变化]

[Changes in the sensitivity of the alpha 2- and beta 1-adrenoreactive systems during the intensive cooling of rats acclimatized to cold].

作者信息

Kulinskiĭ V I, Gertsov G E, Plotnikov N Iu, Bezachev V G

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1988 Aug;74(8):1120-5.

PMID:2848728
Abstract

Cold-acclimated rats with an increased resistance against intensive cold, differ from ordinary animals by increased beta 1- and decreased alpha 2-adrenoreactivity in ordinary conditions; their beta 1-adrenoreactive systems preserve sensitivity at intensive cold exposure (up to hypothermia below 25 degrees C), whereas the sensitivity of their alpha 2-adrenoreactive systems declines more rapidly (up to a moderate hypothermia--33-34 degrees C). The data obtained suggest the described shifts to be important for essential increase in general resistance against acute intensive cold exposure in rats.

摘要

对强烈寒冷具有增强抵抗力的冷适应大鼠,在正常情况下与普通动物不同,其β1 - 肾上腺素反应性增加而α2 - 肾上腺素反应性降低;它们的β1 - 肾上腺素反应系统在强烈寒冷暴露(直至体温低于25摄氏度的低温)时仍保持敏感性,而其α2 - 肾上腺素反应系统的敏感性下降得更快(直至中度低温——33 - 34摄氏度)。所获得的数据表明,上述变化对于大鼠总体抵抗急性强烈寒冷暴露的本质性增强很重要。

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