Neurology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, 34212, Saudi Arabia.
Vasc Health Risk Manag. 2022 Apr 14;18:267-276. doi: 10.2147/VHRM.S349912. eCollection 2022.
Spontaneous simultaneous bilateral basal ganglia hemorrhage (SSBBGH) is an extremely rare condition with only a few published case reports and series. However, there is no systematic review that has been published yet.
The study aims to conduct a systematic review on spontaneous simultaneous bilateral basal ganglion bleeding and a descriptive statistical analysis of collected data on epidemiology, clinical features, etiology, therapeutic approach and prognosis. This review aims to be a clinical reference for busy clinicians when they are faced with such a rare condition.
This review has been carried out in accordance with recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.
Review of 60 cases showed that SSBBGH affected predominantly male patients (70%) with an average age of 50.8 ± 15.33 years and the male-to-female ratio was 2.5:1. The female patients tend to be older with an average age of 54.22 ± 16.67 years. Location of SSBBGHwas more common in the putamen (90% vs 10% non-putaminal). SSBBGH posed a significant mortality rate (33.33%). Among patients who survived, only 40.6% (13/32 report) have had favorable outcomes (mRS ≤2) and the remaining 59.4% (19/32) ended up with poor functional status (mRS ≥3-5). The most common implicated etiologies were hypertension followed by alcohol intoxication.
SSBBGH is a rare clinical entity with significant morbidity and mortality. Systemic approach can lead to early recognition of etiology and prompt treatment. Hypertension and the putamen are the most common etiology and location of SSBBGH, respectively. History of hypertension and age can help narrow differential diagnosis and limit unnecessary testing or intervention.
自发性双侧基底节出血（SSBBGH）极为罕见，仅有少数病例报告和系列报道。然而，目前尚未发表系统评价。
本研究旨在对自发性双侧基底节出血进行系统评价，并对收集到的流行病学、临床特征、病因、治疗方法和预后数据进行描述性统计分析。该综述旨在为忙碌的临床医生在面对这种罕见疾病时提供临床参考。
本研究按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行。
对 60 例病例的回顾表明，SSBBGH 主要影响男性患者（70%），平均年龄为 50.8±15.33 岁，男女比例为 2.5:1。女性患者年龄较大，平均年龄为 54.22±16.67 岁。SSBBGH 的位置更常见于壳核（90%比非壳核 10%）。SSBBGH 的死亡率很高（33.33%）。在存活的患者中，仅有 40.6%（32 例中有 13 例）的预后良好（mRS≤2），其余 59.4%（32 例中有 19 例）的功能状态较差（mRS≥3-5）。最常见的潜在病因是高血压，其次是酒精中毒。
SSBBGH 是一种罕见的临床实体，具有较高的发病率和死亡率。系统的方法可以及早识别病因并及时治疗。高血压和壳核分别是 SSBBGH 最常见的病因和位置。高血压病史和年龄有助于缩小鉴别诊断范围，并限制不必要的检查或干预。
