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岩藻依聚糖处理高密度HT-29结肠癌细胞后细胞死亡和细胞周期的差异。

Differences in cell death and cell cycle following fucoidan treatment in high-density HT-29 colon cancer cells.

作者信息

Kim In-Hye, Kwon Mi-Jin, Nam Taek-Jeong

机构信息

Cell Biology Laboratory, Institute of Fisheries Sciences, Pukyong National University, Busan 46041, Republic of Korea.

出版信息

Mol Med Rep. 2017 Jun;15(6):4116-4122. doi: 10.3892/mmr.2017.6520. Epub 2017 Apr 27.

DOI:10.3892/mmr.2017.6520
PMID:28487956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5436236/
Abstract

Fucoidan, a sulfated polysaccharide present in marine brown seaweed, has been demonstrated to inhibit in vivo and in vitro growth of cells. The present study was conducted in HT‑29 human colon cancer cells cultured at a high density, and examined the potential underlying mechanisms by which fucoidan exerts its anti‑proliferative effects, which remain poorly understood. Fucoidan treatment of high‑density HT‑29 cells resulted in the inhibition of cell growth and increased apoptotic cell death. Flow cytometric analysis revealed that fucoidan treatment led to sub‑G1 phase cell cycle arrest. This was associated with decreased protein expression levels of Retinoblastoma protein and E2 factor protein. In conclusion, the results of the present study demonstrated that fucoidan possesses anticancer activity against high density HT‑29 cells by inhibiting cell growth and cell cycle progression.

摘要

岩藻依聚糖是一种存在于海洋褐藻中的硫酸化多糖，已被证明能在体内和体外抑制细胞生长。本研究以高密度培养的HT-29人结肠癌细胞进行，探讨了岩藻依聚糖发挥抗增殖作用的潜在机制，而这些机制目前仍知之甚少。用岩藻依聚糖处理高密度HT-29细胞可导致细胞生长受到抑制，凋亡性细胞死亡增加。流式细胞仪分析显示，岩藻依聚糖处理导致细胞周期停滞于亚G1期。这与视网膜母细胞瘤蛋白和E2因子蛋白的表达水平降低有关。总之，本研究结果表明，岩藻依聚糖通过抑制细胞生长和细胞周期进程，对高密度HT-29细胞具有抗癌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5832/5436236/19d937d3895c/MMR-15-06-4116-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5832/5436236/736fc575e280/MMR-15-06-4116-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5832/5436236/1d15368eab24/MMR-15-06-4116-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5832/5436236/80f980da1464/MMR-15-06-4116-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5832/5436236/19d937d3895c/MMR-15-06-4116-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5832/5436236/736fc575e280/MMR-15-06-4116-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5832/5436236/1d15368eab24/MMR-15-06-4116-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5832/5436236/80f980da1464/MMR-15-06-4116-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5832/5436236/19d937d3895c/MMR-15-06-4116-g03.jpg

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