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仅有任意性是不够的:迈向一种关于遗传密码的功能方法。

Arbitrariness is not enough: towards a functional approach to the genetic code.

作者信息

Lacková Ľudmila, Matlach Vladimír, Faltýnek Dan

机构信息

Department of General Linguistics, Palacký University, Křížkovského 14, 771 47, Olomouc, Czech Republic.

出版信息

Theory Biosci. 2017 Dec;136(3-4):187-191. doi: 10.1007/s12064-017-0246-1. Epub 2017 May 9.

Abstract

Arbitrariness in the genetic code is one of the main reasons for a linguistic approach to molecular biology: the genetic code is usually understood as an arbitrary relation between amino acids and nucleobases. However, from a semiotic point of view, arbitrariness should not be the only condition for definition of a code, consequently it is not completely correct to talk about "code" in this case. Yet we suppose that there exist a code in the process of protein synthesis, but on a higher level than the nucleic bases chains. Semiotically, a code should be always associated with a function and we propose to define the genetic code not only relationally (in basis of relation between nucleobases and amino acids) but also in terms of function (function of a protein as meaning of the code). Even if the functional definition of meaning in the genetic code has been discussed in the field of biosemiotics, its further implications have not been considered. In fact, if the function of a protein represents the meaning of the genetic code (the sign's object), then it is crucial to reconsider the notion of its expression (the sign) as well. In our contribution, we will show that the actual model of the genetic code is not the only possible and we will propose a more appropriate model from a semiotic point of view.

摘要

遗传密码中的任意性是采用语言学方法研究分子生物学的主要原因之一

遗传密码通常被理解为氨基酸与核碱基之间的一种任意关系。然而,从符号学的角度来看,任意性不应是定义密码的唯一条件,因此在这种情况下谈论“密码”并不完全正确。不过我们认为在蛋白质合成过程中存在一种密码,但它处于比核酸碱基链更高的层次。从符号学上讲,密码应始终与一种功能相关联,我们提议不仅从关系角度(基于核碱基与氨基酸之间的关系),而且从功能角度(将蛋白质的功能视为密码的意义)来定义遗传密码。即使遗传密码中意义的功能定义已在生物符号学领域得到讨论,但其进一步的影响尚未得到考虑。事实上,如果蛋白质的功能代表遗传密码的意义(符号的对象),那么重新思考其表达(符号)的概念也至关重要。在我们的论述中,我们将表明遗传密码的实际模型并非唯一可能的模型,并且我们将从符号学角度提出一个更合适的模型。

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