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基因的语言。

The language of genes.

作者信息

Searls David B

机构信息

Bioinformatics Division, Genetics Research, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA.

出版信息

Nature. 2002 Nov 14;420(6912):211-7. doi: 10.1038/nature01255.

Abstract

Linguistic metaphors have been woven into the fabric of molecular biology since its inception. The determination of the human genome sequence has brought these metaphors to the forefront of the popular imagination, with the natural extension of the notion of DNA as language to that of the genome as the 'book of life'. But do these analogies go deeper and, if so, can the methods developed for analysing languages be applied to molecular biology? In fact, many techniques used in bioinformatics, even if developed independently, may be seen to be grounded in linguistics. Further interweaving of these fields will be instrumental in extending our understanding of the language of life.

摘要

自分子生物学诞生以来,语言隐喻就融入了其结构之中。人类基因组序列的测定将这些隐喻带入了大众想象的前沿,自然而然地将DNA作为语言的概念延伸到了基因组作为“生命之书”的概念。但这些类比是否更深入呢?如果是这样,用于分析语言的方法能否应用于分子生物学?事实上,生物信息学中使用的许多技术,即使是独立开发的,也可以被视为基于语言学。这些领域的进一步交织将有助于扩展我们对生命语言的理解。

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