Molnar Kristof, Jedlovszky-Hajdu Angela, Zrinyi Miklos, Jiang Shaohua, Agarwal Seema
Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Nagyvarad ter 4, Budapest, H-1089, Hungary.
HAS-SE Molecular Biophysics Research Group, Nagyvárad tér 4, Budapest, H-1089, Hungary.
Macromol Rapid Commun. 2017 Jul;38(14). doi: 10.1002/marc.201700147. Epub 2017 May 10.
Electrospinning is a well-known technique for the preparation of scaffolds for biomedical applications. In this work, a continuous electrospinning method for gel fiber preparation is presented without a spinning window. As proof of concept, the preparation of poly(aspartic acid)-based hydrogel fibers and their properties are described by using poly(succinimide) as shell polymer and 2,2,4(2,4,4)-trimethyl-1,6-hexanediamine as cross-linker in the core of the nozzle. Cross-linking takes place as the two solutions get in contact at the tip of the nozzle. The impact of solution concentrations and feeding rates on fiber morphology, proof of the presence of cross-links as well as pH sensitivity after the transformation of the poly(succinimide)-based material to poly(aspartic acid) is presented.
静电纺丝是一种用于制备生物医学应用支架的知名技术。在这项工作中，提出了一种无需纺丝窗口的连续静电纺丝方法来制备凝胶纤维。作为概念验证，描述了以聚琥珀酰亚胺为壳聚合物、2,2,4(2,4,4)-三甲基-1,6-己二胺为喷嘴芯部交联剂的聚天冬氨酸基水凝胶纤维的制备及其性能。当两种溶液在喷嘴尖端接触时发生交联。研究了溶液浓度和进料速率对纤维形态的影响、交联存在的证据以及聚琥珀酰亚胺基材料转化为聚天冬氨酸后的pH敏感性。
