State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Changzhou Institute of Advanced Materials, Beijing University of Chemical Technology, Changzhou, Jiangsu, 213164, P. R. China.
Macromol Rapid Commun. 2018 Oct;39(20):e1800144. doi: 10.1002/marc.201800144. Epub 2018 May 28.
This study reports an effective method for controlling substance-release sites of hydrogel. Glycidyl methacrylate, which contains two functional groups, namely, double-bond acrylate and epoxide, is photografted on a hydrogel surface through hydrogen abstraction photopolymerization due to the existence of a hydrogen donor, such as an amine, in the hydrogel matrix. The remaining epoxide group crosslinks the polymer chain of polyglycidyl methacrylate. Substance release of hydrogel is changed due to the altered surface texture of hydrogel. Rate and site-controlled substance release are achieved by controlling the thickness and site of surface grafting and the extent of epoxide ring opening. This study may provide a novel method for achieving hydrogel function or modified performance of other biomaterials to meet biological activity requirements.
本研究报告了一种控制水凝胶药物释放部位的有效方法。甲基丙烯缩水甘油酯含有两个官能团，即双键丙烯酯和环氧基，由于水凝胶基质中存在供氢体，如胺，通过氢提取光聚合被光接枝到水凝胶表面。剩余的环氧基交联聚甲基丙烯缩水甘油酯的聚合物链。水凝胶的物质释放由于水凝胶表面纹理的改变而发生变化。通过控制表面接枝的厚度和位置以及环氧环的开环程度，可以实现速率和部位控制的物质释放。本研究可能为实现水凝胶功能或改性其他生物材料的性能以满足生物活性要求提供一种新方法。
