应用 F-氟代脱氧葡萄糖 PET/CT 成像评估股骨颈骨代谢。
Assessment of femoral neck bone metabolism using F-sodium fluoride PET/CT imaging.
机构信息
Departments of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
出版信息
Bone. 2020 Jul;136:115351. doi: 10.1016/j.bone.2020.115351. Epub 2020 Apr 8.
BACKGROUND
Standard of care metabolic bone disease assessment relies on changes to bone quantity, which can only be detected after structural changes occur.
PURPOSE
To investigate the usefulness of Bone Metabolism Score (BMS), derived from fluorine 18 labeled sodium fluoride (F-NaF) PET/CT imaging as a biomarker of localized metabolic changes at the femoral neck.
METHODS
In this retrospective study, 139 participants (68 females and 71 males, ages 21-75 years) that had undergone F-NaF PET/CT were included. BMS was calculated as the ratio of standard uptake value (SUV) in the bone region to that of the total region. Correlations and linear regressions of BMS with age, CT-derived bone mineral density (BMD), body mass index (BMI), height, and weight were conducted. Differences in BMS between women younger and older than the age of 50 years were assessed. Inter- and intra-operator reproducibility was evaluated by coefficient of variation (CV) and intra-class correlation coefficient (ICC).
RESULTS
Among females, age was negatively correlated with left and right whole BMS (5.61% and 4.90% drop in BMS per decade of life) and left and right cortical BMS (10.50% and 10.09% drop in BMS per decade of life). BMS of women older than 50 years was lower than BMS of women younger than 50 years (P < .0001). Among males, age was negatively correlated with left and right whole BMS (4.29% and 4.25% drop in BMS per decade of life) and left and right cortical BMS (9.13% and 10.30% drop in BMS per decade of life). BMD was positively correlated with whole (r = 0.80, P < .0001) and cortical (r = 0.92, P < .0001) BMS.
CONCLUSIONS
BMS could provide functional insight regarding bone metabolism in the femoral neck to complement bone health status assessed through conventional structural imaging. The methodology described herein could be potentially useful for assessing hip fracture risk in individuals when BMD tests provide borderline determination of bone disease.
背景
标准的代谢性骨病评估依赖于骨量的变化，而只有在结构发生变化后才能检测到这种变化。
目的
研究氟 18 标记的氟化钠（F-NaF）PET/CT 成像衍生的骨代谢评分（BMS）作为股颈局部代谢变化的生物标志物的有用性。
方法
在这项回顾性研究中，纳入了 139 名参与者（68 名女性和 71 名男性，年龄 21-75 岁），他们接受了 F-NaF PET/CT 检查。BMS 计算为骨区标准摄取值（SUV）与总区 SUV 的比值。对 BMS 与年龄、CT 骨密度（BMD）、体重指数（BMI）、身高和体重的相关性和线性回归进行了分析。评估了年龄小于或大于 50 岁的女性之间的 BMS 差异。通过变异系数（CV）和组内相关系数（ICC）评估了操作员内和操作员间的可重复性。
结果
在女性中，年龄与左、右侧全 BMS（每十年生活下降 5.61%和 4.90%）和左、右侧皮质 BMS（每十年生活下降 10.50%和 10.09%）呈负相关。年龄大于 50 岁的女性的 BMS 低于年龄小于 50 岁的女性（P<0.0001）。在男性中，年龄与左、右侧全 BMS（每十年生活下降 4.29%和 4.25%）和左、右侧皮质 BMS（每十年生活下降 9.13%和 10.30%）呈负相关。BMD 与全 BMS（r=0.80，P<0.0001）和皮质 BMS（r=0.92，P<0.0001）呈正相关。
结论
BMS 可以提供有关股颈骨代谢的功能见解，以补充通过常规结构成像评估的骨健康状况。本文描述的方法在当 BMD 测试对骨疾病的诊断存在边界问题时，可能对评估个体的髋部骨折风险有用。
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