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实时三维微波监测间质热疗。

Real-Time Three-Dimensional Microwave Monitoring of Interstitial Thermal Therapy.

出版信息

IEEE Trans Biomed Eng. 2018 Mar;65(3):528-538. doi: 10.1109/TBME.2017.2702182. Epub 2017 May 8.

Abstract

We report a method for real-time three-dimensional monitoring of thermal therapy through the use of noncontact microwave imaging. This method is predicated on using microwaves to image changes in the dielectric properties of tissue with changing temperature. Instead of the precomputed linear Born approximation that was used in prior work to speed up the frame-to-frame inversions, here we use the nonlinear distorted Born iterative method (DBIM) to solve the electric volume integral equation (VIE) to image the temperature change. This is made possible by using a recently developed graphic processing unit accelerated conformal finite difference time domain method to solve the forward problem and update the electric field in the monitored region in each DBIM iteration. Compared to our previous work, this approach provides a far superior approximation of the electric field within the VIE, and thus yields a more accurate reconstruction of tissue temperature change. The proposed method is validated using a realistic numerical model of interstitial thermal therapy for a deep-seated brain lesion. With the new DBIM, we reduced the average estimation error of the mean temperature within the region of interest from 2.5 to 1.0 for the noise-free case, and from 2.9 to 1.7 for the 2% background noise case.

摘要

我们报告了一种通过使用非接触微波成象实时三维监测热疗的方法。该方法基于使用微波来成像组织介电特性随温度变化的变化。与之前工作中用于加速帧间反演的预先计算的线性玻恩近似不同,这里我们使用非线性失真的玻恩迭代方法 (DBIM) 来求解电体积积分方程 (VIE) 以成像温度变化。这是通过使用最近开发的图形处理单元加速共形有限差分时域方法来解决正向问题并在每个 DBIM 迭代中更新监测区域中的电场来实现的。与我们之前的工作相比,该方法在 VIE 内提供了对电场的远优近似,从而对组织温度变化进行了更准确的重建。该方法使用深部脑病变的间质热疗的现实数值模型进行了验证。使用新的 DBIM,我们将无噪声情况下感兴趣区域内平均温度的平均估计误差从 2.5 降低到 1.0,将 2%背景噪声情况下的平均估计误差从 2.9 降低到 1.7。

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