Regnier Marie, Auxenfans Céline, Maucort-Boulch Delphine, Marty Anne-Sophie, Damour Odile, Burillon Carole, Kocaba Viridiana
Service d'ophtalmologie Banque de Tissus et de Cellules des Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon Université Claude-Bernard Lyon-I, Villeurbanne Service de Biostatistique, Hospices Civils de Lyon, Lyon CNRS UMR5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France.
Medicine (Baltimore). 2017 May;96(19):e6885. doi: 10.1097/MD.0000000000006885.
The purpose of this article is to examine outcomes of Descemet membrane endothelial keratoplasty (DMEK) performed with cornea bank (CB) prestripped tissue and surgeon stripped tissue (SST).This retrospective study examined subjects who underwent DMEK with CB or surgeon prepared tissue for Fuchs endothelial corneal dystrophy. Best-corrected visual acuity (BCVA), corneal thickness, endothelial cell count (ECC), and complications were examined before and throughout a 6-month postoperative period.Eleven CB and 22 SST subjects were included. Six months after surgery, BCVA was 20/20 or better in 36.4% of CB and 22.7% of SST subjects (P = .43). Median logMAR BCVA was 0.10 (0.00-0.20, 20/25) in group CB and 0.10 (0.10-0.30, 20/25) in group SST. Median preoperative corneal thickness was 614.0 μm (577.5-662.0 μm) and 658.0 μm (606.0-689.0 μm) in CB and SST subjects, respectively (P = .37). Six months after surgery, median corneal thickness was lower in the CB group (571.0 μm [478.0-592.0 μm]), than in the SST group (576.0 μm [531.0-607.0 μm], P = .02). At 6 months, median ECC was 1500.0 cell/mm (1321.5-2049.0 cell/mm, 41% decrease) in group CB and 1403.0 cell/mm (972.5-2010.7 cell/mm, 46% decrease) in group SST (P = .70). Rebubbling was required in 5 CB (45.5%) and 15 SST (68.2%) subjects (P = .39).Fuchs' dystrophy patients have good anatomic and functional DMEK results. Similar outcomes and complication rates occurred with eye bank and surgeon prepared donor tissue.
本文旨在研究使用角膜库预剥离组织和术者剥离组织（SST）进行的Descemet膜内皮角膜移植术（DMEK）的效果。这项回顾性研究考察了因Fuchs内皮角膜营养不良而接受角膜库组织或术者准备组织的DMEK手术的受试者。在术前及术后6个月的整个期间，对最佳矫正视力（BCVA）、角膜厚度、内皮细胞计数（ECC）及并发症进行了检查。纳入了11例使用角膜库组织和22例使用术者剥离组织的受试者。术后6个月，36.4%使用角膜库组织的受试者及22.7%使用术者剥离组织的受试者的BCVA达到20/20或更好（P = 0.43）。角膜库组织组的平均对数最小分辨角视力（logMAR BCVA）为0.10（0.00 - 0.20，20/25），术者剥离组织组为0.10（0.10 - 0.
