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PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice.PKC 和 PKA 调节活体小鼠神经肌肉接头处的 AChR 动态。
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突触下区域作为神经肌肉接头处CHRN回收优先位点的证据。

Evidence for the subsynaptic zone as a preferential site for CHRN recycling at neuromuscular junctions.

作者信息

Wild Franziska, Khan Muzamil Majid, Rudolf Rüdiger

机构信息

a Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences , Mannheim , Germany.

b Interdisciplinary Center for Neurosciences, Heidelberg University , Heidelberg , Germany.

出版信息

Small GTPases. 2019 Sep;10(5):395-402. doi: 10.1080/21541248.2017.1324939. Epub 2017 Jun 8.

DOI:10.1080/21541248.2017.1324939
PMID:28489965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6748366/
Abstract

Vertebrate skeletal muscle contraction is mediated by nicotinic acetylcholine receptors (CHRN). Endocytosis and recycling of CHRN regulate their proper abundance at nerve-muscle synapses, i.e. neuromuscular junctions. Recent work showed that RAB5 is essential for CHRN endocytosis. Here, using in vivo-imaging of endocytosed CHRN and RAB-GFP fusion proteins, we deliver evidence for differential effects of RAB5-GFP, RAB4-GFP, and RAB11-GFP on CHRN endocytosis. Furthermore, while newly endocytosed CHRN colocalized with RAB5-GFP over large stretches of muscle fibers, RAB4-GFP and RAB11-GFP colocalized with endocytosed CHRN almost exclusively at neuromuscular junctions. In agreement with previous findings, this data suggests the existence of a specialized subsynaptic zone that is particularly relevant for CHRN recycling.

摘要

脊椎动物骨骼肌收缩由烟碱型乙酰胆碱受体（CHRN）介导。CHRN的内吞作用和再循环调节其在神经肌肉突触（即神经肌肉接头）处的适当丰度。最近的研究表明，RAB5对CHRN内吞作用至关重要。在此，通过对内吞的CHRN和RAB-GFP融合蛋白进行体内成像，我们提供了RAB5-GFP、RAB4-GFP和RAB11-GFP对CHRN内吞作用产生不同影响的证据。此外，虽然新内吞的CHRN在大片肌纤维上与RAB5-GFP共定位，但RAB4-GFP和RAB11-GFP几乎仅在神经肌肉接头处与内吞的CHRN共定位。与先前的研究结果一致，该数据表明存在一个对CHRN再循环特别重要的特殊突触下区域。