Rayner Genevieve
Postdoctoral Fellow, Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre (Austin), Heidelberg, Australia Honorary Fellow, Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Australia.
Epilepsy Curr. 2017 Mar-Apr;17(2):78-83. doi: 10.5698/1535-7511.17.2.78.
This review poses the question: Does disruption to cognitive brain networks in epilepsy contribute to the problem of comorbid depression? Initial evidence suggests that the network disease that gives rise to seizures has a predilection for the same cognition-related networks that regulate mood, with comorbidity reflective of more extensive disease. Framing both epilepsy and its psychiatric comorbidities in terms of dysfunction in overlapping (cognitive) networks raises the possibility that depression can be a primary feature of the disease in some cases and facilitates an epilepsy classification system where behavioral features of the disorder are embedded in a neurobiological mechanism.
癫痫中认知脑网络的破坏是否会导致共病性抑郁症问题？初步证据表明，引发癫痫发作的网络疾病倾向于影响调节情绪的相同认知相关网络，共病反映了更广泛的疾病。从重叠（认知）网络功能障碍的角度来阐释癫痫及其精神科共病，这增加了在某些情况下抑郁症可能是该疾病主要特征的可能性，并有助于建立一个将该疾病行为特征纳入神经生物学机制的癫痫分类系统。
