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本文引用的文献

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Dual Antagonism of PDGF and VEGF in Neovascular Age-Related Macular Degeneration: A Phase IIb, Multicenter, Randomized Controlled Trial.抗 PDGF 和抗 VEGF 双重阻断治疗新生血管性年龄相关性黄斑变性的 IIb 期、多中心、随机对照临床试验
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Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration.光生物调节可减少干性年龄相关性黄斑变性患者的玻璃膜疣体积，并提高视力和对比敏感度。
Acta Ophthalmol. 2017 Jun;95(4):e270-e277. doi: 10.1111/aos.13354. Epub 2016 Dec 18.
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Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases.干细胞研究进展——神经退行性疾病更好诊断与预后的一线希望
Front Mol Biosci. 2016 Nov 8;3:72. doi: 10.3389/fmolb.2016.00072. eCollection 2016.
4
Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration.2a期随机临床试验：视网膜下注射重组腺相关病毒.sFLT-1治疗湿性年龄相关性黄斑变性的安全性及事后分析
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Current advances in the treatment of neovascular age-related macular degeneration.新生血管性年龄相关性黄斑变性的当前治疗进展
Expert Opin Drug Deliv. 2017 Feb;14(2):273-282. doi: 10.1080/17425247.2016.1213240. Epub 2016 Aug 2.
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Update on Clinical Trials in Dry Age-related Macular Degeneration.干性年龄相关性黄斑变性临床试验的最新进展
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Single-Chain Antibody Fragment VEGF Inhibitor RTH258 for Neovascular Age-Related Macular Degeneration: A Randomized Controlled Study.单链抗体片段 VEGF 抑制剂 RTH258 治疗新生血管性年龄相关性黄斑变性：一项随机对照研究。
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黄斑变性管理与认识方面的最新进展。

Recent advances in the management and understanding of macular degeneration.

作者信息

Bahadorani Sepehr, Singer Michael

机构信息

University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Medical Center Ophthalmology Associates, San Antonio, TX, USA.

出版信息

F1000Res. 2017 Apr 20;6:519. doi: 10.12688/f1000research.10998.1. eCollection 2017.

DOI:10.12688/f1000research.10998.1
PMID:28491291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5399962/
Abstract

Current management of age-related macular degeneration (AMD) is directed at intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors for the treatment of wet AMD and supplementation with oral antioxidants for the treatment of dry AMD. In this article, we will review recent clinical trials for the treatment of dry and wet AMD.

摘要

年龄相关性黄斑变性（AMD）的当前治疗方法是针对湿性AMD进行玻璃体内注射血管内皮生长因子（VEGF）抑制剂，以及针对干性AMD进行口服抗氧化剂补充治疗。在本文中，我们将回顾治疗干性和湿性AMD的近期临床试验。