一只患有慢性肾衰竭的猫的肾嗜酸细胞瘤。
Renal oncocytoma in a cat with chronic renal failure.
作者信息
Lee Sora, Choi Hyun-Ji, Lee Han-Byul, Jo Sung-Min, Mun Ji-Hye, Son Woo-Chan
机构信息
Asan Institute for Life Sciences and Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Department of Clinical Pathology, Irion Animal Hospital, Seoul, Korea.
出版信息
JFMS Open Rep. 2017 Feb 1;3(1):2055116917693491. doi: 10.1177/2055116917693491. eCollection 2017 Jan-Jun.
CASE SUMMARY
A 9-year-old male neutered domestic shorthair cat presented with anorexia. Ultrasonography showed an irregularly shaped hypoechoic mass in the cranial pole of the right kidney. Ultrasound-guided fine-needle aspiration of the renal mass was performed. Cytology revealed moderate cellularity smears composed of epithelial cell clusters, which consisted of an exclusive population of oncocytic cells seen in sheets and papillary clusters along with abundant single cells. A moderate-to-abundant amount of densely stained granular cytoplasm with round nuclei and indistinct nucleoli was seen. The cytological diagnosis was renal oncocytic neoplasm. CT and surgical resection revealed a firm tan mass in the right kidney. A final diagnosis of renal oncocytoma was made on the basis of histology, immunohistochemical staining profile (positive for cytokeratin, and negative for chromogranin A, neuron-specific enolase and vimentin) of neoplastic cells, together with the electronic microscopy results.
RELEVANCE AND NOVEL INFORMATION
We believe that this is the first report of the cytological features of feline renal oncocytoma.
病例摘要
一只9岁已绝育的雄性家养短毛猫出现厌食症状。超声检查显示右肾头极有一个形状不规则的低回声肿块。对肾脏肿块进行了超声引导下细针穿刺抽吸。细胞学检查显示涂片细胞中度丰富，由上皮细胞簇组成，这些细胞簇由成片和乳头状簇状排列的嗜酸性细胞瘤细胞组成，还有大量单个细胞。可见大量深染的颗粒状细胞质，细胞核圆形，核仁不明显。细胞学诊断为肾嗜酸性细胞瘤。CT和手术切除显示右肾有一个质地坚实的黄褐色肿块。根据肿瘤细胞的组织学、免疫组化染色特征（细胞角蛋白阳性，嗜铬粒蛋白A、神经元特异性烯醇化酶和波形蛋白阴性）以及电子显微镜检查结果，最终诊断为肾嗜酸细胞瘤。
相关性和新信息
我们认为这是关于猫肾嗜酸细胞瘤细胞学特征的首次报道。
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