Chiu Elliott S, Vernau William, Armién Anibal G, Affolter Verena K
Department of Pathology, Microbiology, and Immunology, University of California-Davis, Davis, CA, USA.
Department of Veterinary Clinical Sciences, City University of Hong Kong, Hong Kong, China.
J Vet Diagn Invest. 2025 May 1:10406387251332203. doi: 10.1177/10406387251332203.
A large renal mass was identified by ultrasound during a regular health check on an intact adult female chimpanzee (). Cytology revealed a neoplastic population of clusters of polygonal cells with distinctive pink, granular cytoplasm. The primary differentials were oncocytoma and renal chromophobe cell carcinoma. The mass was surgically resected and grossly it effaced >75% of the right kidney and had a central scar. Histology confirmed an oncocytoma based on characteristic morphology, diffuse expression of cKIT (CD117), and limited expression of CK7, both assessed via immunohistochemistry. Transmission electron microscopy identified the granular component of the cytoplasm as mitochondria. Renal oncocytoma has not been reported previously in a great ape, to our knowledge. Our case appears nearly identical to the frequently reported and well-characterized human counterpart.
在对一只成年雌性黑猩猩进行常规健康检查时，超声检查发现一个较大的肾脏肿物。细胞学检查显示，肿瘤细胞群为多边形细胞簇，细胞质呈独特的粉红色颗粒状。主要鉴别诊断为嗜酸细胞瘤和肾嫌色细胞癌。该肿物经手术切除，大体观察发现其占据右肾超过75%，并有一个中央瘢痕。组织学检查通过免疫组织化学评估，依据特征性形态、cKIT（CD117）的弥漫性表达以及CK7的有限表达，确诊为嗜酸细胞瘤。透射电子显微镜检查确定细胞质中的颗粒成分是线粒体。据我们所知，此前尚未有在大型猿类中报道过肾嗜酸细胞瘤的情况。我们的病例与经常报道且特征明确的人类病例几乎相同。
