Bountouvi Evangelia, Douros Konstantinos, Papadopoulou Anna
Third Department of Pediatrics, Athens University Medical School, University General Hospital "Attikon", Athens, Greece.
Front Pediatr. 2017 Apr 26;5:87. doi: 10.3389/fped.2017.00087. eCollection 2017.
The worldwide increase in asthma prevalence during the last decades and the re-emergence of vitamin D deficiency in many populations hinted toward an underlying association between these two conditions. Since asthma is presented with high incidence in childhood and neonatal vitamin D stores depend on maternal vitamin levels, a possible programming effect of maternal vitamin D status during gestation was suggested. Observational and longitudinal studies on this subject led to inconclusive results with glimmer of positivity. In the randomized controlled clinical trials (RCTs) that followed, increased doses of vitamin D were tested in pregnant women being at high risk of having an asthmatic child. Although, the results of RCTs showed a potential association with asthma-related phenotypes rather than asthma , the low toxicity of vitamin D supplements make it tempting to speculate that pregnant women at a high risk of obtaining a child with asthma may be benefited, especially if they are vitamin D deficient.
在过去几十年中，全球哮喘患病率不断上升，且许多人群中维生素D缺乏问题再度出现，这暗示了这两种情况之间可能存在潜在关联。由于哮喘在儿童期发病率较高，且新生儿的维生素D储备取决于母亲的维生素水平，因此有人提出孕期母亲维生素D状态可能存在编程效应。关于这一主题的观察性研究和纵向研究结果尚无定论，但有一些积极的迹象。在随后的随机对照临床试验（RCT）中，对有生育哮喘患儿高风险的孕妇进行了高剂量维生素D测试。尽管RCT结果显示与哮喘相关表型而非哮喘存在潜在关联，但维生素D补充剂毒性低，这使得人们不禁推测，有生育哮喘患儿高风险的孕妇可能会从中受益，尤其是那些维生素D缺乏的孕妇。
