Papadopoulou Anna, Bountouvi Evangelia, Papaevaggelou Vasiliki, Priftis Kostas N
Third Department of Pediatrics, Athens University Medical School, University General Hospital "Attikon", 1 Rimini Str, 12464 - Haidari, Athens-Greece.
Mini Rev Med Chem. 2015;15(11):900-12. doi: 10.2174/1389557515666150519105741.
Vitamin D has an indisputable immunodulatory role in both lung and immune system development, which is initiated during fetal life and is mainly accomplished in the first years of extrauterine life. Several published studies have shown that low levels of vitamin D may increase the risk of developing asthma and allergic diseases. Moreover, vitamin D deficiency epidemic reported over the last decades coincides with an increase in the prevalence of asthma and allergies in westernized societies. Since placental transfer of 25(OH)D is the major source of vitamin D in the developing fetus, important questions concerning the impact of maternal vitamin D status on the outcome of pregnancy have arisen. The aim of this review is to present the current evidence regarding the determinants of vitamin D status in pregnancy as well as its role in the development of asthma and allergies in early childhood.
维生素D在肺部和免疫系统发育过程中具有无可争议的免疫调节作用，这一过程始于胎儿期，并主要在出生后的头几年完成。多项已发表的研究表明，低水平的维生素D可能会增加患哮喘和过敏性疾病的风险。此外，过去几十年报道的维生素D缺乏流行情况与西方社会哮喘和过敏症患病率的增加相吻合。由于25(OH)D的胎盘转运是发育中胎儿维生素D的主要来源，因此出现了关于母体维生素D状态对妊娠结局影响的重要问题。本综述的目的是介绍有关孕期维生素D状态的决定因素及其在幼儿哮喘和过敏症发展中作用的现有证据。
