两家三级护理新生儿重症监护病房12年期间（2000 - 2011年）侵袭性真菌感染的流行病学研究

Epidemiology of Invasive Fungal Infections at Two Tertiary Care Neonatal Intensive Care Units Over a 12-Year Period (2000-2011).

作者信息

Agarwal Roshani R, Agarwal Rajkumar L, Chen Xinguang, Lua Jorge L, Ang Jocelyn Y

机构信息

Children's Hospital of Michigan, Detroit, MI, USA.

Wayne State University, Detroit, MI, USA.

出版信息

Glob Pediatr Health. 2017 Mar 30;4:2333794X17696684. doi: 10.1177/2333794X17696684. eCollection 2017.

DOI:10.1177/2333794X17696684

PMID:28491922

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5406153/

Abstract

We conducted a retrospective review of 168 patients with invasive fungal infections from January 2000 to December 2011 in 2 neonatal intensive care units. Patients with bloodstream infection (BSI, n = 152) were further analyzed. was the most common species overall (47%); however, there was an increase in non- sp from 2006 to 2011. BSI clearance rates were lower in extremely low birth weight infants (77% vs 93%, = .01) and in patients with infections (77% vs 91%, = .01). Clearance rates improved from 2000 to 2005 (70% - 90%) to 2006 to 2011 (86% -100%). Combination antifungal use increased during the later years (73% vs 49%, < .05) and in patients with end-organ dissemination (83% vs 54%, < .05). We concluded that extremely low birth weight infants and infection are factors associated with nonclearance of BSI. Successful clearance of BSI improved in 2006 to 2011, perhaps due to increase in non- species and the use of combination antifungals.

摘要

我们对2000年1月至2011年12月期间在2个新生儿重症监护病房的168例侵袭性真菌感染患者进行了回顾性研究。对152例血流感染（BSI）患者进行了进一步分析。总体而言，[某种真菌名称]是最常见的菌种（47%）；然而，从2006年到2011年，非[该真菌名称]菌种有所增加。极低出生体重儿的BSI清除率较低（77%对93%，P = 0.01），[另一种感染相关情况]患者的清除率也较低（77%对91%，P = 0.01）。清除率从2000年至2005年的70% - 90%提高到了2006年至2011年的86% - 100%。联合使用抗真菌药物在后期有所增加（73%对49%，P < 0.05），在有终末器官播散的患者中也是如此（83%对54%，P < 0.05）。我们得出结论，极低出生体重儿和[感染相关情况]感染是与BSI清除失败相关的因素。2006年至2011年BSI的成功清除有所改善，可能是由于非[该真菌名称]菌种的增加以及联合抗真菌药物的使用。