准分子激光治疗与窄谱中波紫外线治疗剥脱性唇炎
Excimer laser therapy and narrowband ultraviolet B therapy for exfoliative cheilitis.
作者信息
Bhatia Bhavnit K, Bahr Brooks A, Murase Jenny E
机构信息
Rush Medical College, Rush University Medical Center, Chicago, IL, USA.
Department of Dermatology, Stanford University, Palo Alto, CA, USA.
出版信息
Int J Womens Dermatol. 2015 Apr 10;1(2):95-98. doi: 10.1016/j.ijwd.2015.01.006. eCollection 2015 Jun.
BACKGROUND
Exfoliative cheilitis is a condition of unknown etiology characterized by hyperkeratosis and scaling of vermilion epithelium with cyclic desquamation. It remains largely refractory to treatment, including corticosteroid therapy, antibiotics, antifungals, and immunosuppressants.
OBJECTIVE
We sought to evaluate the safety and efficacy of excimer laser therapy and narrowband ultraviolet B therapy in female patients with refractory exfoliative cheilitis.
METHODS
We reviewed the medical records of two female patients who had been treated unsuccessfully for exfoliative cheilitis. We implemented excimer laser therapy, followed by hand-held narrowband UVB treatments for maintenance therapy, and followed them for clinical improvement and adverse effects.
RESULTS
Both patients experienced significant clinical improvement with minimal adverse effects with excimer laser therapy 600-700 mJ/cm twice weekly for several months. The most common adverse effects were bleeding and burning, which occurred at higher doses. The hand-held narrowband UVB unit was also an effective maintenance tool.
LIMITATIONS
Limitations include small sample size and lack of standardization of starting dose and dose increments.
CONCLUSION
Excimer laser therapy is a well-tolerated and effective treatment for refractory exfoliative cheilitis with twice weekly laser treatments of up to 700 mJ/cm. Transitioning to the hand-held narrowband UVB device was also an effective maintenance strategy.
背景
剥脱性唇炎是一种病因不明的疾病，其特征为唇红上皮角化过度和脱屑，并伴有周期性脱皮。包括皮质类固醇疗法、抗生素、抗真菌药和免疫抑制剂在内的治疗方法对其大多无效。
目的
我们旨在评估准分子激光疗法和窄谱中波紫外线疗法对难治性剥脱性唇炎女性患者的安全性和有效性。
方法
我们回顾了两名剥脱性唇炎治疗失败的女性患者的病历。我们实施了准分子激光疗法，随后采用手持式窄谱中波紫外线治疗进行维持治疗，并对她们进行临床改善情况及不良反应的随访。
结果
两名患者在每周两次、持续数月、剂量为600 - 700 mJ/cm²的准分子激光治疗后均有显著的临床改善，且不良反应极小。最常见的不良反应是出血和灼痛，在较高剂量时出现。手持式窄谱中波紫外线设备也是一种有效的维持治疗工具。
局限性
局限性包括样本量小以及起始剂量和剂量递增缺乏标准化。
结论
准分子激光疗法是一种耐受性良好且有效的难治性剥脱性唇炎治疗方法，每周两次激光治疗，剂量可达700 mJ/cm²。过渡到手持式窄谱中波紫外线设备也是一种有效的维持治疗策略。
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