Taneja Atul, Trehan Manju, Taylor Charles R
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Int J Dermatol. 2003 Aug;42(8):658-62. doi: 10.1046/j.1365-4362.2003.01997.x.
Vitiligo is commonly treated with PUVA, and more recently, narrow-band UVB (NBUVB) phototherapy. Given the proximity of the wavelengths of NBUVB (311 nm) and the excimer laser (308 nm), we undertook a clinical trial to test the efficacy of this device.
Twice-weekly 308-nm UV-B radiation was given to selected vitiligo lesions for a maximum of 60 treatments. These lesions had been unsuccessfully treated previously with at least one other method of treatment. Initial doses were 100 mJ/cm2 with increments of 10-25%. Improvement was assessed on a visual scale via serial photographs.
Subjects tolerated the treatment well. Improvement varied with body site. After 60 treatments, lesions on the hands and feet showed grade 2 improvement in 2/10 subjects and grade 1 in 8/10. For the axillae, there was grade 4 improvement in 1/3 subjects and grade 2 improvement in 2/3 by treatment 60. The face demonstrated the most rapid repigmentation with grade 4 repigmentation seen in 3/5 subjects by 40 treatments and grade 3 in 2/5 by 30 treatments. There were no adverse effects.
The user-friendly 308-nm excimer laser allows targeted treatments of localized vitiligo.
白癜风通常采用补骨脂素加长波紫外线（PUVA）治疗，近来也采用窄谱中波紫外线（NBUVB）光疗。鉴于NBUVB（311纳米）和准分子激光（308纳米）波长相近，我们开展了一项临床试验以测试该设备的疗效。
选定的白癜风皮损每周接受两次308纳米UV - B照射，最多照射60次。这些皮损此前至少采用过一种其他治疗方法但未成功。初始剂量为100毫焦/平方厘米，每次递增10 - 25%。通过系列照片以视觉评分法评估改善情况。
受试者对治疗耐受性良好。改善情况因身体部位而异。60次治疗后，手部和足部皮损在2/10的受试者中显示2级改善，8/10的受试者显示1级改善。腋窝部位，到第60次治疗时，1/3的受试者有4级改善，2/3的受试者有2级改善。面部色素恢复最快，40次治疗后3/5的受试者有4级色素恢复，30次治疗后2/5的受试者有3级色素恢复。未出现不良反应。
用户友好型的308纳米准分子激光可对局限性白癜风进行靶向治疗。
