皮肤科医生免疫原性指南。
A dermatologist guide to immunogenicity.
作者信息
Blattner Collin M, Chaudhari Soham P, Young John, Murase Jenny E
机构信息
Good Samaritan Regional Medical Center, Corvallis, Oregon.
Hackensack University Medical Center Palisades, North Bergen, New Jersey.
出版信息
Int J Womens Dermatol. 2016 Jul 18;2(3):77-84. doi: 10.1016/j.ijwd.2016.05.001. eCollection 2016 Sep.
Dermatologists should be aware that autoantibody formation may occur after the initiation of biologic therapy. This phenomenon has been referred to as immunogenicity and biologic fatigue. Because of this, patients may experience loss of clinical efficacy to a particular drug. To combat this phenomenon, low-dose immunomodulators may be used in hopes of preventing autoantibodies. We review the current literature and provide a basic treatment algorithm for patients with moderate to severe psoriasis.
皮肤科医生应意识到，生物治疗开始后可能会出现自身抗体形成。这种现象被称为免疫原性和生物制剂疲劳。因此，患者可能会出现对特定药物临床疗效的丧失。为应对这一现象，可使用低剂量免疫调节剂以预防自身抗体的产生。我们回顾了当前的文献，并为中重度银屑病患者提供了一个基本的治疗方案。
Zotero 插件